{"id":"W4393087526","doi":"10.1158/1538-7445.am2024-7130","title":"Abstract 7130: Dysregulated DNA repaired elicited by type 1 PRMT inhibitor in clear cell renal cell carcinoma enables development of novel combination therapies","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Renal and related cancers","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; University of Toronto","funders":"","keywords":"Cancer research; DNA; Renal cell carcinoma; Clear cell renal cell carcinoma; Cell; Internal medicine; Medicine; Biology; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164891,0.0003353617,0.0006010468,0.0002612429,0.0001710498,0.000441343,0.0002470703,0.0003635989,0.003646158],"category_scores_gemma":[0.000143541,0.0001228703,0.0003877972,0.0002297712,0.0001458669,0.0002228407,0.0001746536,0.0008359589,0.0008990857],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002922932,"about_ca_system_score_gemma":0.000288814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006089659,"about_ca_topic_score_gemma":0.001009848,"domain_scores_codex":[0.9998199,0.00001760547,0.00001337706,0.00004735343,0.00007120913,0.00003061215],"domain_scores_gemma":[0.9999195,0.00001122304,0.00002036268,0.00001128353,0.00001712754,0.00002043994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002507385,0.00008195568,0.0003554468,0.0001103389,0.0000177954,0.00007965,0.00001052967,0.0001487594,0.9928053,0.0000811614,0.000487796,0.005570482],"study_design_scores_gemma":[0.00005698789,0.001407288,0.005595193,0.00001254777,0.00006746833,0.000541895,0.00003339873,0.001497711,0.9813871,0.00008100794,0.009308614,0.00001083885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697917,0.01262762,0.006933697,0.0005351743,0.0003074476,0.0001629587,0.003905341,0.0008414048,0.004894657],"genre_scores_gemma":[0.9860802,0.002687622,0.002946894,0.0002259688,0.00002933565,0.00009320921,0.003313217,0.00008269242,0.004540879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003646158,"threshold_uncertainty_score":0.01219761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0291922931898401,"score_gpt":0.3108372527927262,"score_spread":0.2816449596028862,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}