{"id":"W4393088507","doi":"10.1158/1538-7445.am2024-4784","title":"Abstract 4784: PATHFINDER 2: A prospective study to evaluate safety and performance of a multi-cancer early detection test in a population setting","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Molecular Biology Techniques and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Pathfinder; Cancer; Medicine; Test (biology); Population; Prospective cohort study; Gerontology; Environmental health; Oncology; Internal medicine; Computer science; Biology; Library science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01068548,0.0008827737,0.0007326464,0.0005382623,0.0008680223,0.001470942,0.001217174,0.001519524,0.005997946],"category_scores_gemma":[0.01936725,0.0005766291,0.0010832,0.0008417611,0.0007800381,0.001683605,0.001059833,0.001913262,0.001902201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007579579,"about_ca_system_score_gemma":0.001620584,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008405733,"about_ca_topic_score_gemma":0.0009245542,"domain_scores_codex":[0.9954259,0.002362161,0.0003011139,0.001048681,0.0006131636,0.0002489517],"domain_scores_gemma":[0.9817654,0.005642588,0.006365353,0.00240917,0.002410241,0.001407274],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1669567,0.010756,0.7349678,0.001296212,0.003459046,0.0003932112,0.0006107405,0.001051707,0.004081342,0.0009421022,0.01625923,0.05922585],"study_design_scores_gemma":[0.03532193,0.1281141,0.787788,0.0005967602,0.005026464,0.001727678,0.0005203829,0.006328397,0.005195873,0.002795782,0.02634122,0.0002435567],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9699886,0.001832828,0.005306746,0.001069051,0.0002079055,0.003551606,0.01365686,0.0003161759,0.004070273],"genre_scores_gemma":[0.9701609,0.000492993,0.008001193,0.001685377,0.0002260515,0.006818227,0.009944536,0.0001309157,0.002539701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01068548,"threshold_uncertainty_score":0.05651087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03753463260634923,"score_gpt":0.4182071597540086,"score_spread":0.3806725271476594,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}