{"id":"W4393090648","doi":"10.1158/1538-7445.am2024-5795","title":"Abstract 5795: Potent and selective degradation of KAT2A and KAT2B induces profound cell state changes and inhibits growth of AML, SCLC and NEPC model systems","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Cancer research; Degradation (telecommunications); Cell growth; Internal medicine; Biology; Medicine; Genetics; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001005794,0.0003337389,0.0002686221,0.0002216302,0.0001533779,0.000251221,0.0002026344,0.0002021798,0.002187372],"category_scores_gemma":[0.00007047516,0.0001201273,0.0002286414,0.0002095462,0.0001714002,0.0001079935,0.0001862441,0.0004803283,0.0005443759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003346475,"about_ca_system_score_gemma":0.0003150546,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002580632,"about_ca_topic_score_gemma":0.003368143,"domain_scores_codex":[0.9998558,0.00001170236,0.00001525673,0.00002698234,0.00005199614,0.0000382751],"domain_scores_gemma":[0.9999421,0.000008989851,0.00001251723,0.00001132453,0.000006352972,0.00001882332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001198447,0.00004591277,0.0001246357,0.00002875678,0.000006435312,0.00003921951,0.00001008562,0.0001563997,0.9982281,0.00009363479,0.0002091223,0.0009378871],"study_design_scores_gemma":[0.00001259639,0.0002095144,0.001033571,0.000002994034,0.000006791788,0.00007085999,0.000008735021,0.0007127216,0.9962822,0.00001583058,0.001642275,0.000002001077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913794,0.001337765,0.002148251,0.000119947,0.0000333214,0.00004022558,0.001870692,0.0002377905,0.002832721],"genre_scores_gemma":[0.9896596,0.0007293478,0.00166274,0.00004750575,0.000004373312,0.00007055806,0.002715077,0.00004010493,0.005070757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002580632,"threshold_uncertainty_score":0.007317483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04351889389705985,"score_gpt":0.3579222703713668,"score_spread":0.3144033764743069,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}