{"id":"W4393090889","doi":"10.2147/ott.s442504","title":"Progerin Inhibits the Proliferation and Migration of Melanoma Cells by Regulating the Expression of Paxillin","year":2024,"lang":"en","type":"article","venue":"OncoTargets and Therapy","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Aging","funders":"National Natural Science Foundation of China","keywords":"Paxillin; Cell biology; Cancer research; Melanoma; Expression (computer science); Focal adhesion; Chemistry; Biology; Computer science; Phosphorylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009660841,0.0002723893,0.0001684111,0.0002631864,0.0001197973,0.0001497391,0.0001317293,0.0001754179,0.001766738],"category_scores_gemma":[0.00008706727,0.0000827706,0.0002860762,0.0001145227,0.0001344492,0.0001177906,0.0001351048,0.0004048098,0.0002955229],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001119455,"about_ca_system_score_gemma":0.000148069,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003203792,"about_ca_topic_score_gemma":0.0006029981,"domain_scores_codex":[0.9999135,0.000016884,0.000009432935,0.00001632844,0.00002613198,0.00001777394],"domain_scores_gemma":[0.9999571,0.000008081523,0.00001461631,0.000005210036,0.000004994933,0.000009958584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001287771,0.00003852899,0.0002237273,0.00007846321,0.000007215714,0.00004421354,0.000008998567,0.00004437647,0.9968952,0.00004452573,0.00006775954,0.002418085],"study_design_scores_gemma":[0.0000375714,0.0009215095,0.008441554,0.00001533757,0.00003214602,0.0003180041,0.0000370748,0.0007931218,0.9842775,0.00004493402,0.005076737,0.000004560637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883385,0.005657581,0.002232591,0.0001845352,0.00005766872,0.00004192669,0.0003522307,0.0001232437,0.003011788],"genre_scores_gemma":[0.9909949,0.002870054,0.001750557,0.00007663877,0.00001492295,0.00006160542,0.0004817612,0.00001175973,0.003737914],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001766738,"threshold_uncertainty_score":0.005910337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004935137483157524,"score_gpt":0.2134989458768284,"score_spread":0.2085638083936709,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}