{"id":"W4393090939","doi":"10.1158/1538-7445.am2024-5847","title":"Abstract 5847: Characterizing mechanisms of BRAF/MEK inhibitor resistance in BRAF V600 mutant colorectal cancer vs. melanoma","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Colorectal cancer; Melanoma; Mutant; Cancer research; Medicine; Cancer; MEK inhibitor; Mutation; Oncology; Internal medicine; Biology; Genetics; Gene; MAPK/ERK pathway; Kinase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001941391,0.0001924901,0.0002310055,0.0004271766,0.000168841,0.0002398494,0.0001568474,0.0002684406,0.003122206],"category_scores_gemma":[0.0001652368,0.0001116335,0.0002518297,0.0002547977,0.0001252351,0.0001304673,0.000128601,0.0003497434,0.0006788591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002677709,"about_ca_system_score_gemma":0.0001839364,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009107587,"about_ca_topic_score_gemma":0.001068042,"domain_scores_codex":[0.9998404,0.00001587947,0.00001602347,0.00003304873,0.00006696676,0.0000277418],"domain_scores_gemma":[0.9999086,0.00002275397,0.0000157601,0.00001069145,0.00002100823,0.00002128633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0003816681,0.00009256826,0.006362352,0.00008646351,0.00002271423,0.000104162,0.00002871323,0.0001009156,0.9872947,0.00009057842,0.0002338789,0.005201224],"study_design_scores_gemma":[0.00007368416,0.003570372,0.1319766,0.00001770501,0.00008116807,0.002213114,0.0001078209,0.002073108,0.8545933,0.0001437882,0.005137949,0.00001130697],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940317,0.001087866,0.001398052,0.0000666078,0.00001561865,0.00006059674,0.001628437,0.00005376157,0.001657258],"genre_scores_gemma":[0.9913784,0.0005959921,0.002290822,0.00008699328,0.00001036431,0.00009992452,0.002699491,0.0000249996,0.002812978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003122206,"threshold_uncertainty_score":0.01044482,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05001674603240189,"score_gpt":0.3825361320690873,"score_spread":0.3325193860366854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}