{"id":"W4393093045","doi":"10.1158/1538-7445.am2024-1030","title":"Abstract 1030: Concordance between the DESTINY-Breast04 clinical trial assay (4B5[CDx]) and other HER2 IHC assays for HER2-low breast cancer in real-world practice: First phase of a large-scale, multicenter global ring study","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Concordance; Breast cancer; Cancer; Destiny (ISS module); Medicine; Immunohistochemistry; Oncology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02394059,0.0004298073,0.0004429545,0.0008899019,0.0003933175,0.001032508,0.001139427,0.00079206,0.002116462],"category_scores_gemma":[0.02291149,0.0003278902,0.0004965428,0.0006919832,0.0008703931,0.0006353572,0.001047152,0.0006779956,0.001269615],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007666105,"about_ca_system_score_gemma":0.0004798444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001845957,"about_ca_topic_score_gemma":0.002236989,"domain_scores_codex":[0.9809739,0.01213889,0.001303578,0.002458696,0.002755254,0.000369715],"domain_scores_gemma":[0.970987,0.01374639,0.005449839,0.003259441,0.005437587,0.001119673],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01468715,0.0006003061,0.9563846,0.0001983147,0.0009057401,0.00006630009,0.0005344213,0.0007426374,0.006772516,0.0002204717,0.003405511,0.01548213],"study_design_scores_gemma":[0.0009415075,0.005137494,0.977217,0.00004419868,0.0003911283,0.0003856433,0.0002079199,0.003656203,0.007889866,0.0001510817,0.003945031,0.00003297177],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9896049,0.0009289962,0.002408933,0.0001166332,0.00006147667,0.0004481705,0.002292946,0.00008038121,0.004057489],"genre_scores_gemma":[0.9957086,0.00004711196,0.001384406,0.0001219844,0.0000189192,0.0002033707,0.001983209,0.00002234304,0.0005101978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02394059,"threshold_uncertainty_score":0.1266115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2276398584926865,"score_gpt":0.5914306417682521,"score_spread":0.3637907832755656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}