{"id":"W4393094532","doi":"10.1097/fpc.0000000000000529","title":"Effect of CYP2D6 genetic variation on patient-reported symptom improvement and side effects among children and adolescents treated with amphetamines","year":2024,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Neurotransmitter Receptor Influence on Behavior","field":"Neuroscience","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Alberta Children's Hospital; University of Manitoba; University of Calgary","funders":"","keywords":"Pharmacogenetics; CYP2D6; Genetic variation; Medicine; Variation (astronomy); Pharmacology; Genetics; Biology; Genotype; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007616913,0.0002773028,0.0002272983,0.0001220713,0.00007322031,0.0001019375,0.00007338885,0.00004860812,0.000001695637],"category_scores_gemma":[0.00001223779,0.0002199006,0.00003118001,0.0001396668,0.0001549669,0.00006107015,0.00005554761,0.0001168887,0.000001328772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002239484,"about_ca_system_score_gemma":0.00001500809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003458904,"about_ca_topic_score_gemma":0.00000137126,"domain_scores_codex":[0.9986054,0.0001077473,0.000276181,0.0005853295,0.0002019283,0.0002234257],"domain_scores_gemma":[0.999454,0.0001194779,0.0001116325,0.0001536239,0.00002093017,0.0001403301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000135203,0.00004790143,0.1078101,0.0002136843,0.00003011147,0.00003508942,0.0001889744,0.00006932875,0.7925864,0.000001432992,0.000001050534,0.09888075],"study_design_scores_gemma":[0.00104238,0.001333693,0.3270629,0.0001067441,0.0002566262,0.00004152935,7.724555e-7,0.001145458,0.6688401,0.000004094594,0.000007481786,0.0001581618],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980127,0.0003894425,0.00004542363,0.00001090526,0.0001174832,0.001329306,0.00004307295,0.00004303219,0.000008675461],"genre_scores_gemma":[0.9989152,0.0007901315,0.00005279713,0.0001067485,0.00002826898,0.00005072204,0.000004136024,0.00004534662,0.000006671142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2192528,"threshold_uncertainty_score":0.8967286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005995068617892486,"score_gpt":0.2424962790342238,"score_spread":0.2365012104163313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}