{"id":"W4393095493","doi":"10.1158/1538-7445.am2024-1216","title":"Abstract 1216: Pan-RAS inhibition by a tumor-targeted biotherapeutic","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Hospital for Sick Children","funders":"","keywords":"Cancer research; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001009641,0.0004642874,0.0002691759,0.0002962623,0.0001075357,0.000273765,0.000165375,0.0003247506,0.002838631],"category_scores_gemma":[0.00005846523,0.0001025602,0.0002245465,0.0001785156,0.0001126731,0.0001736971,0.0001902886,0.0006014185,0.001021467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002181262,"about_ca_system_score_gemma":0.0001703805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002395021,"about_ca_topic_score_gemma":0.0003437962,"domain_scores_codex":[0.9998965,0.00001628396,0.000009647796,0.00002137243,0.00003214819,0.0000239419],"domain_scores_gemma":[0.999967,0.000005858865,0.000006072551,0.00000590565,0.000005817297,0.000009346658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007069934,0.00006601842,0.0001110428,0.00003628336,0.000003519621,0.00005997469,0.000007529764,0.000113814,0.9950259,0.0001199848,0.0001720925,0.004213059],"study_design_scores_gemma":[0.00002268886,0.0007502127,0.001322141,0.000004734628,0.00001314835,0.0007462545,0.00000728408,0.000497555,0.9892167,0.00004056694,0.007375973,0.000002910812],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9720008,0.005648169,0.008785767,0.0003504103,0.0001280098,0.0002289548,0.001822725,0.0004934776,0.01054163],"genre_scores_gemma":[0.9753408,0.002816122,0.006525738,0.000132272,0.00002369443,0.0001184361,0.002424738,0.0000556925,0.01256251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002838631,"threshold_uncertainty_score":0.009496212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04314403548258395,"score_gpt":0.4096639899753494,"score_spread":0.3665199544927654,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}