{"id":"W4393096561","doi":"10.1158/1538-7445.am2024-6719","title":"Abstract 6719: TriTCE Co-Stim: A next generation trispecific T cell engager platform with integrated CD28 costimulation, engineered to improve responses in the treatment of solid tumors","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Zymeworks (Canada)","funders":"","keywords":"CD28; Cancer research; T cell; Medicine; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001415957,0.0003960833,0.0001535798,0.0002080766,0.000105323,0.0002489122,0.0002632456,0.0003357364,0.002882728],"category_scores_gemma":[0.00008356645,0.0001271473,0.0001550944,0.0001498756,0.0001176025,0.0002180965,0.0002255853,0.0004689839,0.0009640887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002777451,"about_ca_system_score_gemma":0.0001837823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003146419,"about_ca_topic_score_gemma":0.000533601,"domain_scores_codex":[0.9998562,0.00001713015,0.00001006754,0.00002896852,0.00005341167,0.00003424148],"domain_scores_gemma":[0.999951,0.000005174609,0.00001677632,0.00000370817,0.00001041207,0.00001288387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005017144,0.00003220587,0.0001015949,0.00002994517,0.000004311522,0.00003037992,0.000009339143,0.0002645513,0.9968379,0.0002281012,0.0002483739,0.00216318],"study_design_scores_gemma":[0.000009786017,0.0002217107,0.0003096139,0.000002296144,0.000007087572,0.0001123,0.000006370416,0.001266768,0.994549,0.00002091791,0.00348996,0.000004112846],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9625261,0.001621263,0.02576552,0.0002254864,0.00008610428,0.0001768346,0.001167595,0.0004729262,0.007958117],"genre_scores_gemma":[0.9609774,0.0009540681,0.02541376,0.0002106234,0.00002080319,0.0001903786,0.001758297,0.0001009875,0.01037358],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002882728,"threshold_uncertainty_score":0.009643674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.175562463836538,"score_gpt":0.4376241271590631,"score_spread":0.2620616633225251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}