{"id":"W4393096624","doi":"10.1158/1538-7445.am2024-4507","title":"Abstract 4507: Discovery of a smart molecular glue: A small-molecular compound selectively degrades Nrf2 in KEAP1-mutated tumor cells, by restoring the broken KEAP1 mutant/Nrf2 interaction","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University; Jewish General Hospital","funders":"","keywords":"Mutant; KEAP1; Biology; Cancer research; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001957841,0.0006096445,0.0005938001,0.0003133322,0.0001460418,0.0003622147,0.0005557434,0.0005718324,0.00344827],"category_scores_gemma":[0.0001421965,0.0002129919,0.0005085841,0.0002359092,0.0001820825,0.0003676518,0.0003451708,0.000729103,0.001724744],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002692321,"about_ca_system_score_gemma":0.0002848352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003923108,"about_ca_topic_score_gemma":0.0006663355,"domain_scores_codex":[0.9998962,0.00001672788,0.000008347033,0.00002773054,0.00003168734,0.00001925541],"domain_scores_gemma":[0.9999498,0.000004144719,0.00001258111,0.000004543765,0.00001040274,0.00001845854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005551126,0.0003884324,0.0004136458,0.0005867342,0.00009188856,0.0004196234,0.00003042809,0.00230293,0.966189,0.001388733,0.002575964,0.02505754],"study_design_scores_gemma":[0.0004583471,0.0051853,0.001282551,0.00006176366,0.000159108,0.0008743891,0.00002621026,0.005862212,0.9461696,0.0003979671,0.03945794,0.0000644997],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9013932,0.02267311,0.04073786,0.001729731,0.0006300163,0.001160307,0.006423193,0.001804462,0.02344816],"genre_scores_gemma":[0.9396542,0.01052894,0.02560268,0.0007316041,0.00005533775,0.0003627634,0.005337605,0.0001281415,0.01759879],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00344827,"threshold_uncertainty_score":0.01153564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.062281249297254,"score_gpt":0.3519876591340617,"score_spread":0.2897064098368077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}