{"id":"W4393096624","doi":"10.1158/1538-7445.am2024-4507","title":"Abstract 4507: Discovery of a smart molecular glue: A small-molecular compound selectively degrades Nrf2 in KEAP1-mutated tumor cells, by restoring the broken KEAP1 mutant/Nrf2 interaction","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University; Jewish General Hospital","funders":"","keywords":"Mutant; KEAP1; Biology; Cancer research; Genetics; Transcription factor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009937662,0.0002624799,0.000359717,0.0001598542,0.0001390484,0.0002904603,0.000527284,0.0001629272,0.0002229884],"category_scores_gemma":[0.000345562,0.0001815266,0.0001697114,0.0007938473,0.0002987089,0.0002040006,0.0002076626,0.00132455,0.00001273488],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007597433,"about_ca_system_score_gemma":0.0003145696,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004884059,"about_ca_topic_score_gemma":0.0004350113,"domain_scores_codex":[0.9973393,0.0002857485,0.0004024293,0.0006861434,0.000638905,0.0006474504],"domain_scores_gemma":[0.9982197,0.00104405,0.00009698111,0.0003763884,0.0001614821,0.0001013691],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003851468,0.0002242387,0.001146909,0.0003872763,0.0001341017,0.0003306431,0.0001570003,0.00005667154,0.9934798,0.00005544582,0.0003657399,0.003277048],"study_design_scores_gemma":[0.00023297,0.00007117997,0.001520466,0.00069268,0.00001923125,0.00001697932,0.0004115553,0.000334688,0.9929663,0.0002576869,0.003256364,0.0002198858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934174,0.003635522,0.00003575819,0.0004687144,0.0001248103,0.0002693377,0.0001868087,0.00006039044,0.001801255],"genre_scores_gemma":[0.9990024,0.0003619635,0.00001764419,0.00002856164,0.00009345805,0.0002055646,0.00001923406,0.00004446768,0.000226701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005585001,"threshold_uncertainty_score":0.7402439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.062281249297254,"score_gpt":0.3519876591340617,"score_spread":0.2897064098368077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}