{"id":"W4393096830","doi":"10.1158/1538-7445.am2024-6028","title":"Abstract 6028: Preferential tumor-to-normal tissue biodistribution and single-dose efficacy with ABD147, a DLL3-targeted engineered antibody-based radiotherapeutic, in preclinical small cell lung cancer models","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"iCo Therapeutics (Canada)","funders":"","keywords":"Biodistribution; Medicine; Cancer; Pathology; Radioimmunotherapy; Lung cancer; Cancer research; Antibody; Monoclonal antibody; Internal medicine; Biology; In vivo; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001208302,0.0003972214,0.0006545804,0.0007751966,0.0001753231,0.0002370369,0.0002986787,0.0001836878,0.0003533897],"category_scores_gemma":[0.0001614947,0.000319105,0.00009007876,0.001492076,0.0004031047,0.0002107851,0.0001714744,0.001549569,0.00001696479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001674773,"about_ca_system_score_gemma":0.002399958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002399639,"about_ca_topic_score_gemma":0.001010195,"domain_scores_codex":[0.9955509,0.0002223278,0.0005280899,0.001088986,0.001244333,0.001365387],"domain_scores_gemma":[0.9978344,0.0005325656,0.00005035972,0.0005021027,0.0004810545,0.0005994909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01420003,0.001530575,0.02204948,0.009715792,0.0009600052,0.001115807,0.002722939,0.01067851,0.9016027,0.00008786179,0.003406866,0.03192941],"study_design_scores_gemma":[0.02921245,0.006267001,0.1820139,0.01473187,0.0006600465,0.00005869483,0.0004187441,0.1190781,0.6231992,0.00008149933,0.0221797,0.002098779],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9577973,0.03379665,0.001429401,0.00279751,0.0002257101,0.003083903,0.000392443,0.000181351,0.0002956773],"genre_scores_gemma":[0.9955969,0.00170733,0.0004925978,0.0001059209,0.0004946467,0.0009990748,0.0001277906,0.0001049077,0.000370767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2784036,"threshold_uncertainty_score":0.9999261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1032360579378852,"score_gpt":0.4506887193218676,"score_spread":0.3474526613839823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}