{"id":"W4393096830","doi":"10.1158/1538-7445.am2024-6028","title":"Abstract 6028: Preferential tumor-to-normal tissue biodistribution and single-dose efficacy with ABD147, a DLL3-targeted engineered antibody-based radiotherapeutic, in preclinical small cell lung cancer models","year":2024,"lang":"en","type":"article","venue":"Cancer Research","topic":"Lung Cancer Research Studies","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"iCo Therapeutics (Canada)","funders":"","keywords":"Biodistribution; Medicine; Cancer; Pathology; Radioimmunotherapy; Lung cancer; Cancer research; Antibody; Monoclonal antibody; Internal medicine; Biology; In vivo; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002859205,0.0004539274,0.0005177586,0.0003890853,0.0001401023,0.0003058929,0.0002963213,0.0005235835,0.001544242],"category_scores_gemma":[0.0001862948,0.0001839894,0.0003459246,0.0001769947,0.0003228394,0.0002895827,0.0001445191,0.0008193747,0.0006787006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004666816,"about_ca_system_score_gemma":0.0004283005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00173865,"about_ca_topic_score_gemma":0.001152312,"domain_scores_codex":[0.9997603,0.00003438151,0.00001896471,0.00005707756,0.00006475975,0.00006453785],"domain_scores_gemma":[0.9997969,0.00003840898,0.00004648989,0.00002631125,0.00003740716,0.00005443821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006397585,0.0002422243,0.0001519239,0.00004092184,0.000007171026,0.00004586387,0.00002213397,0.0002005957,0.9968588,0.00005836369,0.0001365584,0.001595671],"study_design_scores_gemma":[0.00006611098,0.002907401,0.001329036,0.000003565826,0.00001524921,0.0001444375,0.00001322323,0.001529259,0.9930087,0.00002550451,0.0009522478,0.000005340014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933645,0.0008379765,0.003225937,0.0001172722,0.00003515458,0.0001189862,0.000619899,0.0002038706,0.001476458],"genre_scores_gemma":[0.9884821,0.0006129841,0.003453918,0.00007817679,0.00001151337,0.0001587364,0.001443218,0.0001111055,0.0056482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00173865,"threshold_uncertainty_score":0.005165994,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1032360579378852,"score_gpt":0.4506887193218676,"score_spread":0.3474526613839823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}