{"id":"W4393111302","doi":"10.1186/s12974-024-03069-9","title":"Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis","year":2024,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; St. Michael's Hospital","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Stichting MS Research; Berlin Institute of Health; Bundesministerium für Bildung und Forschung; European Commission; Deutsche Forschungsgemeinschaft; Amsterdam University Medical Centers; Deutsches Zentrum für Herz-Kreislaufforschung; Hersenstichting; Regeneron Pharmaceuticals","keywords":"TRPV4; Neuroinflammation; Blood–brain barrier; Microglia; Multiple sclerosis; Pathogenesis; Inflammation; Extravasation; Endothelium; Endothelial stem cell; Cell biology; Immunology; Biology; Neuroscience; Medicine; Transient receptor potential channel; Central nervous system; Receptor; In vitro; Internal medicine; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005943545,0.0002291105,0.0003041735,0.0007537946,0.0001831307,0.000272638,0.0001749758,0.0001132605,0.00008097389],"category_scores_gemma":[0.001957406,0.0001947052,0.0001732644,0.0008420391,0.00005120107,0.001491255,0.00004601528,0.0005117448,0.00005295868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008274092,"about_ca_system_score_gemma":0.00009612061,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000682308,"about_ca_topic_score_gemma":0.00001377762,"domain_scores_codex":[0.9976386,0.0002623491,0.0009424133,0.000325091,0.0005642484,0.0002672615],"domain_scores_gemma":[0.9985171,0.0006591668,0.0003897065,0.0001831388,0.0001398062,0.0001110907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001078707,0.00001559758,0.0002033785,0.00005402,0.00001894594,0.0001112197,0.001122394,0.001129234,0.9777782,0.0004205503,0.0005412385,0.01849738],"study_design_scores_gemma":[0.001568652,0.0003638909,0.01018302,0.0002742153,0.00006816674,0.0003884732,0.0001504494,0.009316045,0.9690035,0.001446531,0.006971238,0.000265802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913598,0.0001305501,0.0008534206,0.003059386,0.003777401,0.0002487535,0.000005137462,0.00008796217,0.0004775459],"genre_scores_gemma":[0.99814,0.0001527618,0.00006654807,0.0001340842,0.001074364,0.00001311193,0.000001563431,0.00003320154,0.0003844174],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01823158,"threshold_uncertainty_score":0.7939847,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06181718825888721,"score_gpt":0.253669968238107,"score_spread":0.1918527799792198,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}