{"id":"W4393145192","doi":"10.1042/bst20231570","title":"Scaffolds and the scaffolding domain: an alternative paradigm for caveolin-1 signaling","year":2024,"lang":"en","type":"review","venue":"Biochemical Society Transactions","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Scaffold; Scaffold protein; Computational biology; Caveolin 1; Domain (mathematical analysis); Chemistry; Cell biology; Nanotechnology; Signal transduction; Biology; Computer science; Materials science; Mathematics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003743026,0.0004918711,0.0007469216,0.00002813456,0.0003544774,0.0001497959,0.000341132,0.0006522309,0.00001259925],"category_scores_gemma":[0.00001229825,0.0003345408,0.001522529,0.0001850342,0.0004722299,0.000007714414,0.0000395712,0.0002488329,0.000004293195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004779718,"about_ca_system_score_gemma":0.0002144948,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001615548,"about_ca_topic_score_gemma":0.000004260004,"domain_scores_codex":[0.9981353,0.00006858013,0.0004498622,0.0008026132,0.0001651198,0.0003785545],"domain_scores_gemma":[0.9991785,0.000105451,0.000137362,0.0003528779,0.00006241065,0.0001633973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006796907,0.001066094,7.58128e-7,0.09027962,0.01669921,0.00001636439,0.004895685,0.00006410393,0.09103269,0.007048091,0.0163422,0.7718755],"study_design_scores_gemma":[0.0008546545,0.00009154976,1.337883e-8,0.001230168,0.002814041,0.00009583599,0.0002721308,0.0001646796,0.01240891,0.001420875,0.9800329,0.0006142497],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004646413,0.9574406,0.04040283,0.0001491356,0.0002599334,0.0008784645,0.000328363,0.00004039594,0.00003565914],"genre_scores_gemma":[0.002655474,0.9931083,0.001349798,0.0001333695,0.001090529,0.0005958281,0.0005688435,0.0001014776,0.0003964088],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9636907,"threshold_uncertainty_score":0.9999107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0271432725400811,"score_gpt":0.3131516084953341,"score_spread":0.286008335955253,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}