{"id":"W4393155263","doi":"10.1101/2024.03.20.585993","title":"Eukaryotic Elongation Factor 2 Kinase EFK-1/eEF2K promotes starvation resistance by preventing oxidative damage in <i>C. elegans</i>","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"BC Cancer Agency; Natural Sciences and Engineering Research Council of Canada; Conquer Cancer Foundation; National Institutes of Health; Universities Space Research Association; University of California, San Diego; BC Children's Hospital; Canadian Institutes of Health Research; Faculty of Medicine, University of British Columbia","keywords":"Elongation; Starvation; Elongation factor; Oxidative damage; Cell biology; Chemistry; Kinase; Oxidative stress; Oxidative phosphorylation; Biology; Biochemistry; Gene; Materials science; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008367051,0.0003677704,0.0001851703,0.0002368626,0.0002132941,0.0002507295,0.0001718286,0.0002605442,0.001590322],"category_scores_gemma":[0.00007305769,0.0001481245,0.0001888446,0.0000838875,0.0001916225,0.0001425622,0.0002262173,0.0003552736,0.0005285066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003526894,"about_ca_system_score_gemma":0.0002008279,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007830723,"about_ca_topic_score_gemma":0.001676661,"domain_scores_codex":[0.9999439,0.000003711045,0.0000039469,0.00001860083,0.00001424803,0.00001564538],"domain_scores_gemma":[0.9999516,0.000004799258,0.0000126487,0.000005549764,0.000006684801,0.00001872717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008686566,0.0000148,0.000191625,0.00003234274,0.000002537162,0.00003410963,0.000003338792,0.00005767223,0.9982449,0.00009386982,0.0002040361,0.001033935],"study_design_scores_gemma":[0.00002313905,0.00006645139,0.009269879,0.00001153323,0.00001011279,0.0001289127,0.00001055631,0.001269715,0.9853866,0.0001025348,0.00371332,0.000007285951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871607,0.002370991,0.003262909,0.0003300721,0.0001393751,0.00001929859,0.001177066,0.0003650382,0.00517453],"genre_scores_gemma":[0.9877239,0.000679661,0.002590496,0.00009554284,0.00001790994,0.00002076991,0.0009731675,0.00008325816,0.007815242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001590322,"threshold_uncertainty_score":0.005320132,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008342803177725705,"score_gpt":0.2143218000954144,"score_spread":0.2059789969176887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}