{"id":"W4393164179","doi":"10.1371/journal.ppat.1012100","title":"Deubiquitinating activity of SARS-CoV-2 papain-like protease does not influence virus replication or innate immune responses in vivo","year":2024,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Leids Universitair Medisch Centrum; HORIZON EUROPE European Research Council; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; European Commission; University of Bern","keywords":"Biology; Innate immune system; Viral replication; Virus; Virology; Deubiquitinating enzyme; Immune system; Mutant; Proteases; Protease; ISG15; Coronavirus; Ubiquitin; Microbiology; Immunology; Genetics; Gene; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001438501,0.0004076303,0.0002421772,0.0001071349,0.0001200063,0.0003325339,0.0001588463,0.0002719966,0.0009310095],"category_scores_gemma":[0.0001228845,0.000134991,0.0002195475,0.00008391094,0.0002432732,0.000220314,0.0001431938,0.0005796534,0.0002204102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002369321,"about_ca_system_score_gemma":0.0001491321,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003642715,"about_ca_topic_score_gemma":0.0004878381,"domain_scores_codex":[0.9997858,0.00004203492,0.00002821402,0.00005252446,0.00004275037,0.00004860953],"domain_scores_gemma":[0.9998484,0.00003225861,0.00003882887,0.00003204276,0.00001416136,0.00003424604],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008096333,0.00002465545,0.0001121011,0.00001001567,0.000002970808,0.00002242485,0.0000048463,0.00003687538,0.9993425,0.0000322967,0.00001229405,0.0003179146],"study_design_scores_gemma":[0.000007619293,0.0002287016,0.001889178,0.000001576044,0.000007746517,0.0001284863,0.000008453034,0.0006086251,0.9961197,0.00001965732,0.0009774484,0.000002817641],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966465,0.0006320939,0.001476735,0.00005353132,0.00002658807,0.0000144612,0.0002599091,0.00004400965,0.0008461082],"genre_scores_gemma":[0.996721,0.000283732,0.000790395,0.00002937463,0.000006329416,0.00002043729,0.0004453156,0.00002111138,0.001682348],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009310095,"threshold_uncertainty_score":0.003114462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03749212904206376,"score_gpt":0.3078632402778073,"score_spread":0.2703711112357435,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}