{"id":"W4393166472","doi":"10.1016/j.str.2024.02.021","title":"The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA","year":2024,"lang":"en","type":"article","venue":"Structure","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary; Structural Genomics Consortium; University of Toronto; University Health Network; Princess Margaret Cancer Centre; Sinai Health System; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Hospital for Sick Children; McGill University","keywords":"Transfer RNA; Ribosome; Aminoacylation; Translation (biology); Chemistry; Protein biosynthesis; Context (archaeology); Biochemistry; Aminoacyl tRNA synthetase; Computational biology; Biology; RNA; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000138763,0.0001666509,0.0001331664,0.0000285648,0.0001154998,0.00004999492,0.0002757824,0.0001942396,0.0001666681],"category_scores_gemma":[0.00001919941,0.0001042041,0.0001279946,0.00009235995,0.00008233688,0.000002281128,0.0000668721,0.0001134401,0.000004760456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001173553,"about_ca_system_score_gemma":0.00009411338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002149656,"about_ca_topic_score_gemma":0.00007859835,"domain_scores_codex":[0.9990755,0.00006524944,0.0001486234,0.000304721,0.0001766213,0.0002292917],"domain_scores_gemma":[0.9994038,0.00001995129,0.0000556651,0.0004323591,0.00003207991,0.00005610921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003967353,0.000002955918,0.00005696181,0.00003333329,0.00008969177,0.000004846085,0.0002336077,0.000001039359,0.9862297,0.001372554,0.006955084,0.004980563],"study_design_scores_gemma":[0.0001150197,0.00007251968,0.0001224865,0.00002255777,0.00001794559,0.00002222034,0.0001194096,0.000004505529,0.7908564,0.007828142,0.2007001,0.0001187529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869936,0.008322948,0.0004088494,0.001817027,0.001031603,0.0002831951,0.0003460414,0.00002318219,0.0007735198],"genre_scores_gemma":[0.9965039,0.000229345,0.0005433313,0.0003083763,0.0002071289,0.00001236953,0.00003680734,0.00002884727,0.002129924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1953734,"threshold_uncertainty_score":0.4249322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006823108439203569,"score_gpt":0.2235073176550313,"score_spread":0.2166842092158277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}