{"id":"W4393166698","doi":"10.1016/j.jbc.2024.106176","title":"Abstract 1572 BIOCHEMICAL STUDY OF MUTANTS OF HUMAN ARGINASE I, CAUSING ARGININEMIA","year":2024,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Arginase; Mutant; Chemistry; Biochemistry; Arginine; Gene; Amino acid","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001656193,0.001098607,0.0004021232,0.0004886115,0.0002274366,0.0002925171,0.0004252999,0.0008108767,0.003967043],"category_scores_gemma":[0.0003720224,0.000215715,0.0005871581,0.0002447592,0.0001912313,0.0001856097,0.0002513662,0.0005889718,0.002500659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002634331,"about_ca_system_score_gemma":0.0001258981,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009704969,"about_ca_topic_score_gemma":0.0003188323,"domain_scores_codex":[0.9997692,0.00003278608,0.0000392177,0.00005620949,0.00005526116,0.00004733901],"domain_scores_gemma":[0.9997337,0.00003854191,0.000036831,0.00002180276,0.00006532241,0.0001037081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0013344,0.0002128033,0.003400379,0.0002267743,0.00007984971,0.007742381,0.00008758316,0.0001665073,0.9820701,0.0001607197,0.0007191129,0.003799405],"study_design_scores_gemma":[0.0004490313,0.003150445,0.06125873,0.0001073148,0.0003634834,0.05068322,0.0003240299,0.002326945,0.8387014,0.0004546329,0.0421275,0.00005319367],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.97852,0.006964026,0.002769307,0.0006284972,0.000475251,0.0001128624,0.004016645,0.0001270669,0.006386427],"genre_scores_gemma":[0.9709505,0.002550427,0.003383523,0.0003180085,0.0001532008,0.00007689608,0.01201958,0.0001182464,0.01042955],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003967043,"threshold_uncertainty_score":0.01327109,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02114385238484611,"score_gpt":0.3017292470621425,"score_spread":0.2805853946772964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}