{"id":"W4393166727","doi":"10.1016/j.jbc.2024.106776","title":"Abstract 2067 Tuning HCN channels by interaction of the cytoplasmic C-linker with the transmembrane region","year":2024,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Nicotinic Acetylcholine Receptors Study","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Linker; Transmembrane protein; Cytoplasm; Chemistry; Biophysics; Transmembrane domain; Cell biology; Stereochemistry; Biochemistry; Biology; Computer science; Membrane; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001932998,0.0001604314,0.000102094,0.00004595428,0.0001175769,0.0001983856,0.0001700685,0.0002122619,0.001811144],"category_scores_gemma":[0.0001713695,0.00005868392,0.00008193003,0.00004985202,0.0002353157,0.0001613044,0.0001401909,0.0003556255,0.0002925146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003178153,"about_ca_system_score_gemma":0.0001321415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003773317,"about_ca_topic_score_gemma":0.0007197956,"domain_scores_codex":[0.9999033,0.00001995828,0.00000771868,0.00002170384,0.00002502985,0.00002221025],"domain_scores_gemma":[0.9999042,0.00003137911,0.00002961102,0.000007930493,0.000009361869,0.00001754597],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000051788,0.000009412176,0.0001072654,0.00001165701,0.000001744932,0.00001819479,0.000007313834,0.00005818008,0.9991964,0.0001454338,0.00001377311,0.0003787587],"study_design_scores_gemma":[0.0000249323,0.0001395434,0.001619707,0.000005297828,0.000006871838,0.000125615,0.00002121226,0.001449235,0.9955238,0.00006281725,0.001018093,0.000002793882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962231,0.0002750148,0.002406892,0.00005345758,0.00001057044,0.00001688168,0.00004993636,0.0000207454,0.0009433043],"genre_scores_gemma":[0.9966549,0.0001255436,0.001986819,0.00005566036,0.000005059524,0.00001131108,0.00005592496,0.00001446289,0.001090338],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001811144,"threshold_uncertainty_score":0.006058872,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0161529916192333,"score_gpt":0.2569990263984249,"score_spread":0.2408460347791916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}