{"id":"W4393169232","doi":"10.23977/acss.2024.080120","title":"Deep Learning-Driven Protein Design","year":2024,"lang":"en","type":"article","venue":"Advances in Computer Signals and Systems","topic":"Genetics, Bioinformatics, and Biomedical Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Protein design; Deep learning; Computer science; Artificial intelligence; Biology; Protein structure; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007000694,0.0007397629,0.0007901061,0.000333267,0.0002495181,0.0008838607,0.001293999,0.001042999,0.003071171],"category_scores_gemma":[0.001696624,0.0004443518,0.0005917687,0.0005175578,0.0007621268,0.000973643,0.0009645995,0.001410131,0.0008794687],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001095664,"about_ca_system_score_gemma":0.001375095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001926766,"about_ca_topic_score_gemma":0.004039679,"domain_scores_codex":[0.9997076,0.00007559967,0.00001284297,0.00006485992,0.00008734359,0.00005161978],"domain_scores_gemma":[0.9994401,0.0003211751,0.00003550478,0.00004894671,0.0001139671,0.00004021297],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00007171384,0.00005431204,0.0005793278,0.0001595676,0.00004318862,0.00007432459,0.00003310635,0.8698937,0.003263581,0.04300702,0.005006448,0.07781383],"study_design_scores_gemma":[0.000007563039,0.00001004812,0.00001977949,0.000004509709,0.00000312562,0.000007451766,0.000002536051,0.9871334,0.0004190014,0.01120469,0.001186215,0.000001632739],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.03122352,0.001928637,0.9551442,0.001156731,0.0001549666,0.00006984518,0.0003252106,0.001193726,0.008803215],"genre_scores_gemma":[0.58696,0.001607525,0.3954833,0.0009656333,0.0001349022,0.0003042996,0.001373139,0.0004790438,0.01269212],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003071171,"threshold_uncertainty_score":0.01027405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01866315780523538,"score_gpt":0.2886834292594496,"score_spread":0.2700202714542143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}