{"id":"W4393177493","doi":"10.1016/s2352-3018(23)00300-4","title":"Safety and pharmacokinetics of oral and long-acting injectable cabotegravir or long-acting injectable rilpivirine in virologically suppressed adolescents with HIV (IMPAACT 2017/MOCHA): a phase 1/2, multicentre, open-label, non-comparative, dose-finding study","year":2024,"lang":"en","type":"article","venue":"The Lancet HIV","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":false,"ca_institutions":"GlaxoSmithKline (Canada)","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Child Health and Human Development; National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute of Mental Health; ViiV Healthcare; International Maternal Pediatric Adolescent AIDS Clinical Trials Network; Gilead Sciences","keywords":"Rilpivirine; Medicine; Pharmacokinetics; Pharmacology; Human immunodeficiency virus (HIV); Dolutegravir; Phases of clinical research; Oncology; Internal medicine; Virology; Antiretroviral therapy; Viral load; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008366248,0.0004602511,0.001210891,0.0001926034,0.0002269888,0.0001899888,0.0002881858,0.00007818914,0.00008349308],"category_scores_gemma":[0.0000741807,0.0002645247,0.00002853181,0.0006221466,0.0001484519,0.0003487665,0.0003535548,0.0005946169,0.00001257534],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001171977,"about_ca_system_score_gemma":0.000164026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001751845,"about_ca_topic_score_gemma":0.0005353148,"domain_scores_codex":[0.9975092,0.000215468,0.0006238582,0.000641325,0.0003505196,0.0006596225],"domain_scores_gemma":[0.998906,0.0002669041,0.0002286311,0.0003583846,0.00006893481,0.0001711647],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05085765,0.00802296,0.8703266,0.001526422,0.001639738,0.004201263,0.03111827,0.0002310792,0.01631233,0.00001541684,0.0009885146,0.01475978],"study_design_scores_gemma":[0.3120021,0.008128818,0.5318333,0.01160892,0.003476151,0.001127418,0.01931056,0.08356378,0.02322545,0.00003242102,0.003245437,0.002445627],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946117,0.0005643973,0.0002727563,0.000691285,0.0000766644,0.002669033,0.00004346291,0.00007235858,0.0009982851],"genre_scores_gemma":[0.9955396,0.0003010683,0.001739034,0.00008926756,0.00007627327,0.00007802848,0.00004698938,0.00004517535,0.002084575],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3384933,"threshold_uncertainty_score":0.9999807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08758692114915416,"score_gpt":0.3874615136163261,"score_spread":0.299874592467172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}