{"id":"W4393187966","doi":"10.3390/genes15040416","title":"Association of TMEM106B with Cortical APOE Gene Expression in Neurodegenerative Conditions","year":2024,"lang":"en","type":"article","venue":"Genes","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute","funders":"Canadian Institutes of Health Research","keywords":"Apolipoprotein E; Entorhinal cortex; Neuroscience; Hippocampal formation; Biology; Genome-wide association study; Hippocampus; Reinnervation; Neurodegeneration; Disease; Gene; Single-nucleotide polymorphism; Medicine; Internal medicine; Genetics; Genotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005976056,0.0000683375,0.0001276164,0.00008797168,0.00003138203,0.00001068012,0.00002066779,0.00003712209,0.0001232112],"category_scores_gemma":[0.00002839466,0.00004702963,0.00003540029,0.0001689226,0.00003184753,0.00005512953,0.00001399483,0.00008279112,0.00003193164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006588377,"about_ca_system_score_gemma":0.0001574856,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001308922,"about_ca_topic_score_gemma":0.00001875975,"domain_scores_codex":[0.9992802,0.00005669111,0.0001126832,0.0001535881,0.0002537814,0.0001430617],"domain_scores_gemma":[0.9996511,0.00007714101,0.00002093057,0.00009558049,0.00006129581,0.00009391901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007002872,0.001232242,0.5434012,0.0002343495,0.004333878,0.001204377,0.0004875484,0.0001025836,0.4417325,0.000416445,0.004249466,0.001905141],"study_design_scores_gemma":[0.001954486,0.0006680133,0.2477679,0.0002830283,0.0005383298,0.00002675966,0.0001208775,0.0007939875,0.7472669,0.0001749361,0.0002863811,0.0001183751],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946325,0.004098581,0.00006463067,0.0004120114,0.00004215803,0.0002353568,0.00007814926,0.00002792641,0.0004087254],"genre_scores_gemma":[0.9988447,0.0002283725,0.0003725922,0.00002366823,0.00005625647,0.00005231436,0.0001376021,0.00001100254,0.0002734762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3055344,"threshold_uncertainty_score":0.1917813,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02407079264555267,"score_gpt":0.3275880261509684,"score_spread":0.3035172335054158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}