{"id":"W4393188633","doi":"10.3390/antiox13040396","title":"Endothelial NOX5 Obliterates the Reno-Protective Effect of Nox4 Deletion by Promoting Renal Fibrosis via Activation of EMT and ROS-Sensitive Pathways in Diabetes","year":2024,"lang":"en","type":"article","venue":"Antioxidants","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; McGill University Health Centre","funders":"National Health and Medical Research Council; Monash University; Medical Research Council; Juvenile Diabetes Research Foundation United States of America","keywords":"NOX4; NADPH oxidase; Oxidative stress; Endothelial dysfunction; Reactive oxygen species; Fibrosis; Medicine; Cancer research; Inflammation; Endocrinology; Internal medicine; Cell biology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007158935,0.0002046968,0.0003567503,0.0001685991,0.0001023834,0.00002098383,0.00009319102,0.0001617295,0.00001881095],"category_scores_gemma":[0.0001258912,0.000138388,0.00007644604,0.0003090993,0.0001991303,0.0002131225,0.00006703741,0.0002817231,0.00001186784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002763286,"about_ca_system_score_gemma":0.00002283299,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001748248,"about_ca_topic_score_gemma":0.00001048718,"domain_scores_codex":[0.9982828,0.0007056453,0.0003583498,0.0003404574,0.00005968003,0.0002530325],"domain_scores_gemma":[0.9989877,0.0006090659,0.0001671713,0.0001412765,0.00008180897,0.00001296183],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001940154,0.00004507022,0.0006653064,0.0001726765,0.000118532,0.000002874327,0.001681049,0.000001178799,0.9810172,0.0002008832,0.00001943999,0.01588182],"study_design_scores_gemma":[0.0006822991,0.000866088,0.005006828,0.0006838086,0.00003930764,0.000007748078,0.0001161896,0.0001395796,0.991805,0.0004852618,0.00003862302,0.0001293129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976536,0.0007215969,0.0005806672,0.0001003678,0.0001217599,0.0005783928,0.0001791256,0.0000320129,0.0000324985],"genre_scores_gemma":[0.999696,0.00004909817,0.0000279932,0.00002516817,0.00002474557,0.00004732131,0.00006661259,0.00001988771,0.00004320386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01575251,"threshold_uncertainty_score":0.5643299,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006040328420976545,"score_gpt":0.2121820429673252,"score_spread":0.2061417145463487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}