{"id":"W4393189617","doi":"10.1016/j.jsb.2024.108086","title":"Structural and kinetic analysis of the monofunctional Staphylococcus aureus PBP1","year":2024,"lang":"en","type":"article","venue":"Journal of Structural Biology","topic":"Antimicrobial Resistance in Staphylococcus","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; National Research Council; Canadian Institutes of Health Research; Government of Saskatchewan; Canada Research Chairs; Canada Foundation for Innovation; University of Saskatchewan","keywords":"Penicillin binding proteins; Staphylococcus aureus; Peptidoglycan; Microbiology; Bacterial cell structure; Antibiotics; Cell wall; Antimicrobial; Chemistry; Biology; Penicillin; Bacteria; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001560654,0.0001734064,0.0006052126,0.0004367733,0.00006444236,0.00002225307,0.0001729239,0.0001388339,0.0002482088],"category_scores_gemma":[0.0001434921,0.00009069649,0.0004513182,0.000793219,0.0004634323,0.00007191293,0.00006763329,0.0004215499,8.214515e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000758419,"about_ca_system_score_gemma":0.0001547344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003562842,"about_ca_topic_score_gemma":0.00002373039,"domain_scores_codex":[0.9986898,0.00007466014,0.0006271311,0.0001907001,0.0002103565,0.0002073188],"domain_scores_gemma":[0.9989313,0.0001838818,0.0003312541,0.0001903661,0.0002681878,0.00009498391],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008061596,0.00001057436,0.3310141,0.0001835404,0.00495741,0.00007385942,0.0004179081,0.0004035883,0.6446715,0.004338191,0.0009618289,0.01216132],"study_design_scores_gemma":[0.000516905,0.0003781698,0.9874714,0.00009796501,0.001789891,0.0002680998,0.0001120346,0.001356593,0.003928261,0.002218724,0.00174016,0.0001217775],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930269,0.00459468,0.00008259626,0.001028372,0.0009719424,0.0001211944,0.00007627562,0.000009521944,0.00008854058],"genre_scores_gemma":[0.9988276,0.00008822067,0.0005243733,0.0001532931,0.0002931562,6.523455e-7,0.000007648707,0.00001060958,0.00009443977],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6564573,"threshold_uncertainty_score":0.3698496,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01298266872326726,"score_gpt":0.2867634576573261,"score_spread":0.2737807889340589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}