{"id":"W4393190202","doi":"10.1021/acschembio.4c00106","title":"One Carbon to Rule Them All: Formaldehyde is a One-Carbon Signal Connecting One-Carbon Metabolism and Epigenetic Methylation","year":2024,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Institutes of Health; National Science Foundation","keywords":"Epigenetics; Carbon fibers; DNA methylation; Carbon fixation; Metabolite; Metabolism; Biology; Formaldehyde; Chemistry; Gene; Biochemistry; Gene expression; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004889526,0.0003432218,0.0004450096,0.0001165039,0.00005976503,0.00006046924,0.0002344776,0.0006323656,0.00003247374],"category_scores_gemma":[0.0002503133,0.0003576903,0.0001165994,0.0002255521,0.0001121253,0.000006736902,0.0003267626,0.0002956562,0.000008213459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003949732,"about_ca_system_score_gemma":0.00006179663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001765148,"about_ca_topic_score_gemma":0.00001874901,"domain_scores_codex":[0.9976466,0.000147794,0.0005187357,0.0009212843,0.0001859378,0.0005796921],"domain_scores_gemma":[0.9989802,0.0001613777,0.0001168107,0.0004012543,0.0001113861,0.0002290117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000923304,0.00006429334,0.000639233,0.00004979505,0.0002291098,0.000001179568,0.0002575152,0.000008506542,0.9772823,0.0002672051,0.000006779864,0.02110175],"study_design_scores_gemma":[0.000405747,0.0002544832,0.0004956241,0.00004702219,0.0001819022,0.000004498864,0.00002999707,0.0009691024,0.9867204,0.005071159,0.005375521,0.0004444937],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851136,0.01006025,0.0006367633,0.001085483,0.000217132,0.0003803245,0.00003102695,0.0000648616,0.00241051],"genre_scores_gemma":[0.9949784,0.001132285,0.00231513,0.0005031581,0.0006509599,0.00006284698,0.0002288073,0.0000654688,0.00006297587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02065726,"threshold_uncertainty_score":0.9998875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02902724156518193,"score_gpt":0.2771417535861234,"score_spread":0.2481145120209415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}