{"id":"W4393190202","doi":"10.1021/acschembio.4c00106","title":"One Carbon to Rule Them All: Formaldehyde is a One-Carbon Signal Connecting One-Carbon Metabolism and Epigenetic Methylation","year":2024,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; National Institutes of Health; National Science Foundation","keywords":"Epigenetics; Carbon fibers; DNA methylation; Carbon fixation; Metabolite; Metabolism; Biology; Formaldehyde; Chemistry; Gene; Biochemistry; Gene expression; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000326941,0.0006009354,0.0005712076,0.0004020755,0.0008482994,0.001423861,0.0006082142,0.001186238,0.004636172],"category_scores_gemma":[0.0005689326,0.0002437094,0.0004561382,0.0003557019,0.001071865,0.001897559,0.001071944,0.001695238,0.001539414],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008619801,"about_ca_system_score_gemma":0.0005964478,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044583,"about_ca_topic_score_gemma":0.001994018,"domain_scores_codex":[0.9997739,0.00003550387,0.00001342463,0.00006502885,0.000067539,0.00004448773],"domain_scores_gemma":[0.9997563,0.00006390328,0.00005151567,0.00001903951,0.00005549626,0.0000537086],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004710997,0.00008585271,0.003152686,0.003214513,0.000201698,0.002770341,0.00076531,0.001496836,0.5965385,0.1644921,0.01985349,0.2069577],"study_design_scores_gemma":[0.00001677655,0.000461873,0.003712482,0.0005629566,0.0001334222,0.003077163,0.000638165,0.001321986,0.3779576,0.04838318,0.5635949,0.000139477],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.140572,0.5104071,0.1674535,0.06260023,0.02654324,0.0001594919,0.001683943,0.00138613,0.0891944],"genre_scores_gemma":[0.6481721,0.2267045,0.03587682,0.01458501,0.005974844,0.00008623007,0.000943454,0.0003011721,0.06735584],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.004636172,"threshold_uncertainty_score":0.01550955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02902724156518193,"score_gpt":0.2771417535861234,"score_spread":0.2481145120209415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}