{"id":"W4393192493","doi":"10.1099/mgen.0.001217","title":"Fusobacterium nucleatum subsp. polymorphum recovered from malignant and potentially malignant oral disease exhibit heterogeneity in adhesion phenotypes and adhesin gene copy number, shaped by inter-subspecies horizontal gene transfer and recombination-derived mosaicism","year":2024,"lang":"en","type":"article","venue":"Microbial Genomics","topic":"Otolaryngology and Infectious Diseases","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Health Research Board","keywords":"Fusobacterium nucleatum; Biology; Bacterial adhesin; Virulence; Gene; Microbiology; Genetics; Genome; Subspecies; Intergenic region; Phylogenetic tree; Horizontal gene transfer; Porphyromonas gingivalis; Bacteria","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001016908,0.0002894806,0.0002748535,0.0006608214,0.0003493094,0.0002755866,0.0001107729,0.000253626,0.0006430908],"category_scores_gemma":[0.000372997,0.0001152525,0.0001800659,0.0006743865,0.0001420356,0.00018851,0.0003145132,0.0001371374,0.0001207947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001135105,"about_ca_system_score_gemma":0.0001135633,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003283676,"about_ca_topic_score_gemma":0.002986547,"domain_scores_codex":[0.9998491,0.000009821979,0.00001830824,0.00004807,0.00003722569,0.00003742553],"domain_scores_gemma":[0.9998753,0.00002073051,0.0000385154,0.00001630786,0.0000236251,0.00002556461],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005937851,0.00008328138,0.1837496,0.00008477434,0.00004485471,0.001001555,0.0007295603,0.00008636857,0.8024874,0.00005915263,0.0001466616,0.01093304],"study_design_scores_gemma":[0.00001317577,0.0003653817,0.9574847,0.00001282184,0.00007978749,0.003988615,0.001068859,0.0003612685,0.03517953,0.00009030809,0.00134184,0.00001380753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990082,0.0001502599,0.0002026655,0.00001159928,0.000002495055,0.00001020734,0.000403666,0.000005786142,0.0002051703],"genre_scores_gemma":[0.998274,0.0001141624,0.0004728765,0.00001669534,0.000003715859,0.00001309456,0.0008692754,0.000002894499,0.0002333447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003283676,"threshold_uncertainty_score":0.006529152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009398737099770887,"score_gpt":0.2219321202604512,"score_spread":0.2125333831606803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}