{"id":"W4393195508","doi":"10.1016/j.antiviral.2024.105869","title":"Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals","year":2024,"lang":"en","type":"article","venue":"Antiviral Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; Simon Fraser University; Université de Sherbrooke; University of British Columbia","funders":"GeneTex; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Host (biology); Chemistry; Virology; Mechanism of action; TMPRSS2; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Action (physics); Microbiology; Coronavirus disease 2019 (COVID-19); Biology; Biochemistry; Medicine; Genetics; Physics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002190934,0.0003428702,0.0006338566,0.0006815678,0.0004294628,0.0002694536,0.0003110257,0.0002483618,0.000002994246],"category_scores_gemma":[0.0011674,0.0002260439,0.0001810701,0.002279088,0.0009763705,0.0005284584,0.0004216516,0.001543085,0.00006155147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002497036,"about_ca_system_score_gemma":0.0008877155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001628098,"about_ca_topic_score_gemma":0.0002660364,"domain_scores_codex":[0.9955297,0.0007322544,0.0003652189,0.0008837346,0.001532646,0.000956428],"domain_scores_gemma":[0.997547,0.00111932,0.0001004316,0.0006993467,0.0004950101,0.00003888126],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000849568,0.0002116318,0.01924482,0.0008794989,0.0001821241,0.0002296728,0.0002846762,3.328683e-8,0.9574688,0.00005365,0.0006701936,0.01992531],"study_design_scores_gemma":[0.0008086897,0.0006255697,0.02171409,0.001154429,0.00006784782,0.00003665839,0.0001653032,0.001013137,0.9628602,0.00003008218,0.01128631,0.0002376844],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888511,0.000929744,0.00004225531,0.0007553409,0.0002436403,0.001023143,0.0000315837,0.0002095457,0.007913675],"genre_scores_gemma":[0.9986752,0.00009088306,0.00005211235,0.0004311501,0.0002726173,0.00004747642,0.000002834716,0.00008995653,0.000337758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01968762,"threshold_uncertainty_score":0.9217802,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09663143742622812,"score_gpt":0.4092835361401602,"score_spread":0.3126520987139321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}