{"id":"W4393195508","doi":"10.1016/j.antiviral.2024.105869","title":"Nanomolar anti-SARS-CoV-2 Omicron activity of the host-directed TMPRSS2 inhibitor N-0385 and synergistic action with direct-acting antivirals","year":2024,"lang":"en","type":"article","venue":"Antiviral Research","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Centre for Disease Control; Simon Fraser University; Université de Sherbrooke; University of British Columbia","funders":"GeneTex; Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Host (biology); Chemistry; Virology; Mechanism of action; TMPRSS2; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Action (physics); Microbiology; Coronavirus disease 2019 (COVID-19); Biology; Biochemistry; Medicine; Genetics; Physics; Pathology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001600941,0.0003427285,0.0003600382,0.0001504093,0.0001120395,0.0002396021,0.0002069534,0.000276813,0.001253715],"category_scores_gemma":[0.0001410899,0.0001413794,0.0002138211,0.0001711993,0.0001399296,0.0001243048,0.0001550161,0.0005412315,0.0003179122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002162036,"about_ca_system_score_gemma":0.0002066706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007924488,"about_ca_topic_score_gemma":0.002051018,"domain_scores_codex":[0.9998547,0.00003149893,0.00001643787,0.00001640701,0.0000487563,0.00003216126],"domain_scores_gemma":[0.9999398,0.00002245914,0.00001028441,0.000007362359,0.000007188614,0.00001298381],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003893516,0.0001787983,0.000327623,0.00008206241,0.00002541775,0.0000552935,0.00001771076,0.0003436037,0.9943619,0.00007758947,0.0001704524,0.003970199],"study_design_scores_gemma":[0.0001494763,0.003981464,0.01080625,0.0000143638,0.00005809562,0.0009033213,0.00004329476,0.002732881,0.9766577,0.00006346607,0.00457759,0.00001205245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906337,0.003273318,0.001296021,0.0001140449,0.00005078553,0.0000373443,0.0003204123,0.00009066028,0.004183692],"genre_scores_gemma":[0.9964865,0.0009023838,0.001093985,0.00006823734,0.00001571057,0.00002284131,0.0004934779,0.000006803315,0.0009100044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253715,"threshold_uncertainty_score":0.00419414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09663143742622812,"score_gpt":0.4092835361401602,"score_spread":0.3126520987139321,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}