{"id":"W4393200667","doi":"10.1089/nat.2023.0078","title":"Extracellular Vesicles Loaded with Long Antisense RNAs Repress Severe Acute Respiratory Syndrome Coronavirus 2 Infection","year":2024,"lang":"en","type":"article","venue":"Nucleic Acid Therapeutics","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Infection and Immunity; National Health and Medical Research Council; National Institutes of Health; University of Queensland; National Institute of Mental Health; Universität Basel","keywords":"RNA; Biology; Virology; Coronavirus; Antisense RNA; Virus; RNA-dependent RNA polymerase; RNA virus; Gene; Coronavirus disease 2019 (COVID-19); Genetics; Disease; Medicine; Infectious disease (medical specialty)","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002526174,0.0003929203,0.0002476599,0.00009337191,0.0001733415,0.0001801563,0.0002999684,0.0003453421,0.00008042189],"category_scores_gemma":[0.00001206097,0.0003625521,0.0001777405,0.0002510089,0.0002786975,0.00003308222,0.0001404839,0.000344477,0.0001240672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006111692,"about_ca_system_score_gemma":0.000159418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000911455,"about_ca_topic_score_gemma":0.00001106721,"domain_scores_codex":[0.9978847,0.0001635633,0.0003526999,0.0007940349,0.0003462121,0.0004587875],"domain_scores_gemma":[0.9986444,0.00002193343,0.000115361,0.0009493018,0.00009539337,0.0001736148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002856072,0.0001374391,0.003131334,0.00009711769,0.0007414765,0.001383763,0.000100774,0.00008994651,0.9770823,0.0002115708,0.0002391678,0.01649954],"study_design_scores_gemma":[0.0009690043,0.0007662901,0.009407075,0.0001641261,0.0005972717,0.001526513,0.00004220567,0.0003815088,0.906049,0.0002230655,0.07909023,0.0007836965],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613045,0.0316599,0.005564264,0.00009123104,0.0003874621,0.0003704761,0.00006342478,0.000205607,0.0003531106],"genre_scores_gemma":[0.9966595,0.0006842777,0.0005024179,0.0004092202,0.0002350309,0.0000277102,0.00009336914,0.0001619152,0.001226537],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07885106,"threshold_uncertainty_score":0.9998826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02235807463150166,"score_gpt":0.28051564733898,"score_spread":0.2581575727074783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}