{"id":"W4393204527","doi":"10.1136/rmdopen-2023-003977","title":"Guselkumab provides durable improvement across psoriatic arthritis disease domains: post hoc analysis of a phase 3, randomised, double-blind, placebo-controlled study","year":2024,"lang":"en","type":"article","venue":"RMD Open","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; McGill University","funders":"Medac; Sun Pharma; National Institute for Health and Care Research; Celltrion; Janssen Scientific Affairs; Biogen; Celgene; Novavax; Gilead Sciences; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Medicine; Dactylitis; Psoriatic arthritis; Enthesitis; Psoriasis; Internal medicine; Psoriasis Area and Severity Index; Placebo; Arthritis; Physical therapy; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009014101,0.000422825,0.002018407,0.0003315143,0.0003218451,0.0004219011,0.0003108803,0.00006421521,0.0005297684],"category_scores_gemma":[0.0001729534,0.0003121267,0.0007208413,0.001090382,0.0000919115,0.0003403925,0.0003453889,0.0001590057,0.00005574634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002012763,"about_ca_system_score_gemma":0.0003178511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001693331,"about_ca_topic_score_gemma":0.003098809,"domain_scores_codex":[0.9968522,0.000113016,0.001040244,0.0008028212,0.000629059,0.0005627034],"domain_scores_gemma":[0.9981359,0.0002593198,0.0002371348,0.000770873,0.0002467933,0.0003500342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8997065,0.007987982,0.001989909,0.0003133045,0.03579253,0.002008841,0.003777767,0.0000285715,0.0004370032,0.00006463641,0.0003726029,0.04752036],"study_design_scores_gemma":[0.9692191,0.006117981,0.001169094,0.0004958386,0.01631621,0.000009160879,0.00446352,0.0008645069,0.0002011265,0.00004215923,0.0007718325,0.0003294294],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9692736,0.01146892,0.00002152252,0.0005871675,0.000290988,0.01717922,0.0005170405,0.00008407664,0.0005774349],"genre_scores_gemma":[0.9910088,0.001276072,0.00007831458,0.0001406867,0.0001064711,0.005272642,0.0002720478,0.00005363945,0.00179128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06951264,"threshold_uncertainty_score":0.9999331,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02495347069638302,"score_gpt":0.3598551297031877,"score_spread":0.3349016590068047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}