{"id":"W4393204527","doi":"10.1136/rmdopen-2023-003977","title":"Guselkumab provides durable improvement across psoriatic arthritis disease domains: post hoc analysis of a phase 3, randomised, double-blind, placebo-controlled study","year":2024,"lang":"en","type":"article","venue":"RMD Open","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; McGill University","funders":"Medac; Sun Pharma; National Institute for Health and Care Research; Celltrion; Janssen Scientific Affairs; Biogen; Celgene; Novavax; Gilead Sciences; Amgen; Pfizer; Eli Lilly and Company; Bristol-Myers Squibb; GlaxoSmithKline","keywords":"Medicine; Dactylitis; Psoriatic arthritis; Enthesitis; Psoriasis; Internal medicine; Psoriasis Area and Severity Index; Placebo; Arthritis; Physical therapy; Dermatology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005567656,0.001730046,0.00361636,0.0004090748,0.0005756447,0.001617083,0.0008339126,0.001598902,0.008053987],"category_scores_gemma":[0.003475996,0.000665591,0.004398592,0.000604703,0.001311446,0.001163123,0.0004751633,0.002689043,0.001475665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009059872,"about_ca_system_score_gemma":0.002046524,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006712477,"about_ca_topic_score_gemma":0.00160341,"domain_scores_codex":[0.9980385,0.001051375,0.0001640607,0.0002849971,0.0001640049,0.000297172],"domain_scores_gemma":[0.9972857,0.0009111768,0.0006482558,0.00040084,0.0002910333,0.0004629576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9732955,0.007013513,0.0005817449,0.0006648352,0.002582584,0.00004648921,0.00006554405,0.0003446123,0.006187745,0.00005535762,0.0006896812,0.008472386],"study_design_scores_gemma":[0.8265353,0.161672,0.00594368,0.00004387276,0.002378267,0.00005207158,0.00004023757,0.0004308116,0.001690303,0.0001484351,0.001034039,0.00003096877],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830137,0.002529966,0.001560472,0.0003657126,0.0003915798,0.007823173,0.002397398,0.0001855577,0.001732304],"genre_scores_gemma":[0.9808832,0.001486297,0.002830569,0.000681791,0.0003362815,0.008707555,0.002197951,0.00007959433,0.002796804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008053987,"threshold_uncertainty_score":0.02944493,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02495347069638302,"score_gpt":0.3598551297031877,"score_spread":0.3349016590068047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}