{"id":"W4393215990","doi":"10.1093/cid/ciae173","title":"A Phase 2 Clinical Trial to Evaluate the Safety, Reactogenicity, and Immunogenicity of Different Prime-Boost Vaccination Schedules of 2013 and 2017 A(H7N9) Inactivated Influenza Virus Vaccines Administered With and Without AS03 Adjuvant in Healthy US Adults","year":2024,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; NYU Grossman School of Medicine; Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases; Biomedical Advanced Research and Development Authority; Centers for Disease Control and Prevention; School of Medicine, Emory University; Bavarian Nordic; Université Saint-Louis; Children's Healthcare of Atlanta; BioFire Diagnostics; Baylor College of Medicine; Gilead Sciences; Sanofi; University of Iowa; Bill and Melinda Gates Foundation; York University; Moderna; Pfizer; Georgia Research Alliance; Saint Louis University; Emory University; Duke University; Eli Lilly and Company; Regeneron Pharmaceuticals; National Institutes of Health; Novavax; Sanofi Pasteur; Administration for Strategic Preparedness and Response; U.S. Department of Health and Human Services; Seqirus","keywords":"Reactogenicity; Medicine; Immunogenicity; Vaccination; Virology; Clinical trial; Trivalent influenza vaccine; Influenza vaccine; Immunology; Internal medicine; Antibody","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00228897,0.002227297,0.002357092,0.0003792911,0.0005299614,0.0008362302,0.0008739654,0.001860535,0.006155532],"category_scores_gemma":[0.00181658,0.0007749603,0.001190054,0.0003129426,0.001208407,0.001208348,0.0004146211,0.002444658,0.001165451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006700975,"about_ca_system_score_gemma":0.001844687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000478938,"about_ca_topic_score_gemma":0.001025377,"domain_scores_codex":[0.9992649,0.0003373708,0.00003565503,0.0001746051,0.00006236848,0.0001251253],"domain_scores_gemma":[0.9987088,0.0002638322,0.0003111064,0.0001300298,0.0001316461,0.000454558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9387465,0.04238741,0.0007204867,0.0003257882,0.0003294644,0.00003048715,0.00006891057,0.0002734151,0.005190543,0.00009029351,0.0005716328,0.01126498],"study_design_scores_gemma":[0.617357,0.3797782,0.001176108,0.00001940537,0.0001540465,0.00002364444,0.00001664399,0.0002514826,0.0006956365,0.0001032318,0.0004149148,0.000009687073],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872593,0.001133465,0.0007115635,0.0003126258,0.0002863679,0.008275977,0.0007788939,0.00007462186,0.001167299],"genre_scores_gemma":[0.9651824,0.001401737,0.00346723,0.00115492,0.0004565241,0.0235739,0.001319094,0.00002470066,0.00341944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006155532,"threshold_uncertainty_score":0.02059227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1376051495377837,"score_gpt":0.5015528454513646,"score_spread":0.3639476959135808,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}