{"id":"W4393216398","doi":"10.1002/adhm.202400108","title":"External Trigger Free Charge Switchable Cationic Ligands in the Design of Safe and Effective Universal Heparin Antidote","year":2024,"lang":"en","type":"article","venue":"Advanced Healthcare Materials","topic":"Proteoglycans and glycosaminoglycans research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Heart, Lung, and Blood Institute; British Columbia Knowledge Development Fund; Natural Sciences and Engineering Research Council of Canada; Office of Research Infrastructure Programs, National Institutes of Health; Canadian Institutes of Health Research; National Institutes of Health; Michael Smith Health Research BC; Canada Foundation for Innovation","keywords":"Heparin; Antidote; Protamine; Pharmacology; Fondaparinux; In vivo; Cationic polymerization; Chemistry; Medicine; Thrombosis; Biochemistry; Surgery; Toxicity; Polymer chemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001807473,0.0003784118,0.0001670284,0.0001523712,0.00008990007,0.0002744379,0.0002281029,0.0004230677,0.0005667466],"category_scores_gemma":[0.0001099732,0.0001276558,0.0001017887,0.000145207,0.0001961329,0.0003289115,0.000256993,0.0002865941,0.0002640303],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002729297,"about_ca_system_score_gemma":0.000226688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002249515,"about_ca_topic_score_gemma":0.0003306627,"domain_scores_codex":[0.9999127,0.00001773376,0.000006784132,0.00001758137,0.00002548249,0.00001968547],"domain_scores_gemma":[0.9999585,0.000005761572,0.0000147566,0.000002998435,0.000006590674,0.0000113861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001081241,0.00004882534,0.0001431851,0.0002181915,0.000009498807,0.0001251113,0.00002715511,0.001705399,0.9793071,0.002899331,0.0002235914,0.01518471],"study_design_scores_gemma":[0.00004541598,0.0007868622,0.0004589315,0.00001920105,0.00001854667,0.0002079441,0.00001900321,0.006007669,0.9731517,0.0003683169,0.01889426,0.00002213282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8976138,0.0192558,0.07115939,0.0004959574,0.0001838505,0.0002792816,0.0002309266,0.0003893293,0.01039166],"genre_scores_gemma":[0.957756,0.005859996,0.03152258,0.0001954289,0.00002650201,0.0001554087,0.0001326159,0.00002049814,0.004331012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005667466,"threshold_uncertainty_score":0.001980245,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01254738195085829,"score_gpt":0.3004385133098377,"score_spread":0.2878911313589794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}