{"id":"W4393216838","doi":"10.1101/2024.03.22.586277","title":"Single cell approaches define forebrain neural stem cell niches and identify microglial ligands that enhance precursor-mediated remyelination","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; SickKids Foundation; University of Toronto; University of British Columbia; Hospital for Sick Children; University of British Columbia Hospital; Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Remyelination; Forebrain; Neuroscience; Niche; Neural stem cell; Stem cell; Biology; Cell; Cell biology; Central nervous system; Genetics; Biochemistry; Myelin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001635517,0.0002716491,0.0002864928,0.0002825001,0.0002071062,0.0004641371,0.0001682241,0.0002219469,0.001085845],"category_scores_gemma":[0.000108541,0.0001416142,0.0002096719,0.0001006668,0.0003036573,0.0001715274,0.0002043354,0.0004195235,0.0003453182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003337847,"about_ca_system_score_gemma":0.000277436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001064021,"about_ca_topic_score_gemma":0.003676791,"domain_scores_codex":[0.9998738,0.00001165541,0.000008465895,0.00003561217,0.00004914343,0.00002136138],"domain_scores_gemma":[0.9999253,0.00001687512,0.0000212054,0.000008948917,0.00001143892,0.00001621636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001650889,0.000004556159,0.0002782348,0.00002201909,0.00000279364,0.00001687612,0.0000182201,0.0001285241,0.9983819,0.0001114681,0.00001878487,0.001000165],"study_design_scores_gemma":[0.00000317688,0.00004005964,0.002325819,0.000005621462,0.000006541471,0.00005227274,0.00004915254,0.001373115,0.9950436,0.00009248865,0.001005561,0.00000261273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628664,0.001606007,0.03166057,0.0001035145,0.00004507977,0.00004874587,0.000723694,0.0002019693,0.002743856],"genre_scores_gemma":[0.9693123,0.001131937,0.02545504,0.0000725869,0.00001412774,0.00009951057,0.0005341324,0.00006600925,0.003314304],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001085845,"threshold_uncertainty_score":0.003632545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04335953935846051,"score_gpt":0.2286501814016733,"score_spread":0.1852906420432128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}