{"id":"W4393218885","doi":"10.1371/journal.pone.0298697","title":"THC and sperm: Impact on fertilization capability, pre-implantation in vitro development and epigenetic modifications","year":2024,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Guelph","funders":"","keywords":"Sperm; Human fertilization; Andrology; In vitro fertilisation; Biology; Cannabis; Transcriptome; Capacitation; Embryo; Acrosome reaction; Fertilisation; Embryogenesis; Medicine; Reproductive technology; Cell biology; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002142901,0.0002082743,0.0002416181,0.0003113766,0.0003440651,0.0004354803,0.0002040153,0.0003182143,0.004135867],"category_scores_gemma":[0.0003523272,0.0001493204,0.0003815557,0.0002381422,0.0002918964,0.0001823313,0.0002611557,0.000397815,0.0004995277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004270821,"about_ca_system_score_gemma":0.0004652603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004604434,"about_ca_topic_score_gemma":0.007634255,"domain_scores_codex":[0.9997758,0.00003472945,0.00001895807,0.00005458282,0.0000842203,0.00003168685],"domain_scores_gemma":[0.9998477,0.00003678605,0.00003125089,0.00001479002,0.0000494086,0.00002009525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009706027,0.0001202277,0.01193057,0.0005643379,0.00009430583,0.0003868025,0.0003677914,0.0002420128,0.9630189,0.0004763786,0.0004383424,0.02138981],"study_design_scores_gemma":[0.00004053675,0.002751038,0.2126793,0.0001225811,0.0002588168,0.001180914,0.0006434195,0.0009304674,0.7628455,0.0004526656,0.01803874,0.00005603276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9665506,0.02006095,0.002134882,0.0004291167,0.0001326676,0.00007259385,0.003052346,0.00009601314,0.007470889],"genre_scores_gemma":[0.9770081,0.007926121,0.001530546,0.0001922178,0.00002035223,0.00006920693,0.001612253,0.00002509015,0.01161606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004604434,"threshold_uncertainty_score":0.01383591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06789662112781582,"score_gpt":0.309904286756417,"score_spread":0.2420076656286012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}