{"id":"W4393219724","doi":"10.3390/molecules29071482","title":"Discovery of Acyl-Surugamide A2 from Marine Streptomyces albidoflavus RKJM-0023—A New Cyclic Nonribosomal Peptide Containing an N-ε-acetyl-L-lysine Residue","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nautilus Biosciences (Canada); University of Prince Edward Island","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Fondation Jean-Louis Lévesque","keywords":"Nonribosomal peptide; Streptomyces; Cyclic peptide; Residue (chemistry); Peptide; Gene cluster; Stereochemistry; Lysine; Streptomycetaceae; Chemistry; Nuclear magnetic resonance spectroscopy; Biochemistry; Amino acid; Biosynthesis; Biology; Actinomycetales; Gene; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000188058,0.0003693726,0.0006613578,0.0001945436,0.00006883048,0.0001563733,0.0002448893,0.0001685398,0.0005077861],"category_scores_gemma":[0.0002778579,0.0002808592,0.0002348465,0.0003598006,0.0001403175,0.0003791572,0.0002128734,0.0003521499,0.00005593415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006833993,"about_ca_system_score_gemma":0.0002333075,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006324537,"about_ca_topic_score_gemma":0.001071693,"domain_scores_codex":[0.9978136,0.00008936306,0.0005653256,0.0007560403,0.0003667617,0.0004088944],"domain_scores_gemma":[0.9987774,0.0001728983,0.0001352461,0.0006308697,0.00008853314,0.0001950463],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006208697,0.0001241596,0.002870151,0.0001734425,0.0003409713,0.0003603606,0.0003129255,0.0000121492,0.9604359,0.0002971606,0.004187867,0.03026408],"study_design_scores_gemma":[0.0009999539,0.0007319217,0.02129572,0.001144142,0.0004805666,0.00005248915,0.0002965497,0.0003196568,0.9620838,0.0004221546,0.0117284,0.000444652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989765,0.003972407,0.0001162597,0.00369065,0.0003129389,0.0003248265,0.0001666283,0.0001759141,0.001475325],"genre_scores_gemma":[0.9889227,0.0004107617,0.003953026,0.000393375,0.001035205,0.000001962203,0.0004712808,0.00007230561,0.004739353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02981942,"threshold_uncertainty_score":0.9999644,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371399943799674,"score_gpt":0.2599514982413069,"score_spread":0.2462374988033102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}