{"id":"W4393219724","doi":"10.3390/molecules29071482","title":"Discovery of Acyl-Surugamide A2 from Marine Streptomyces albidoflavus RKJM-0023—A New Cyclic Nonribosomal Peptide Containing an N-ε-acetyl-L-lysine Residue","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Nautilus Biosciences (Canada); University of Prince Edward Island","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Fondation Jean-Louis Lévesque","keywords":"Nonribosomal peptide; Streptomyces; Cyclic peptide; Residue (chemistry); Peptide; Gene cluster; Stereochemistry; Lysine; Streptomycetaceae; Chemistry; Nuclear magnetic resonance spectroscopy; Biochemistry; Amino acid; Biosynthesis; Biology; Actinomycetales; Gene; Bacteria","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009579197,0.0003737317,0.0002416741,0.0002367303,0.0001325089,0.0003139087,0.0001461622,0.0002642701,0.0003515502],"category_scores_gemma":[0.0001525564,0.00007031439,0.0002401672,0.0002872818,0.000141071,0.0001900872,0.0002222506,0.0003007763,0.0002436769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001395389,"about_ca_system_score_gemma":0.0002349081,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005389737,"about_ca_topic_score_gemma":0.0006942847,"domain_scores_codex":[0.9999212,0.00001514032,0.000007948368,0.00001704455,0.0000257776,0.00001285011],"domain_scores_gemma":[0.9998686,0.00001703735,0.00004141658,0.00001153845,0.00001883088,0.00004263156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001161426,0.00001828816,0.0008935924,0.00004754914,0.000009821803,0.0003978392,0.00001869187,0.0001075606,0.9950579,0.00003004707,0.00001921619,0.003283343],"study_design_scores_gemma":[0.00002681499,0.001014546,0.01168604,0.00001056709,0.00005666548,0.001881726,0.0001227262,0.001232069,0.9793609,0.00008178566,0.004506204,0.00001992833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952438,0.001307651,0.002186498,0.00006610458,0.00001889876,0.00002965223,0.0003556846,0.00002572577,0.0007659955],"genre_scores_gemma":[0.9920893,0.0007934404,0.0051469,0.00003229506,0.00001559774,0.00001343243,0.001049898,0.000009306611,0.000849815],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005389737,"threshold_uncertainty_score":0.001176059,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01371399943799674,"score_gpt":0.2599514982413069,"score_spread":0.2462374988033102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}