{"id":"W4393220169","doi":"10.34133/research.0351","title":"The Tricarboxylic Acid Cycle Metabolites for Cancer: Friend or Enemy","year":2024,"lang":"en","type":"article","venue":"Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"National Natural Science Foundation of China","keywords":"Citric acid cycle; Tricarboxylic acid; Metabolic pathway; Carcinogenesis; Glycolysis; Biology; Biochemistry; Metabolism; Anaerobic glycolysis; Cell cycle; Fumarase; Cell biology; Chemistry; Cell; Enzyme; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001028264,0.0001135322,0.0001348622,0.00007942385,0.0003290569,0.0001784236,0.000346779,0.0001071897,0.00005215355],"category_scores_gemma":[0.0003737168,0.00006924631,0.0001340947,0.0003746467,0.0001671897,0.000004801753,0.0001450459,0.0001908017,0.00001943707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002587644,"about_ca_system_score_gemma":0.0005705353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001095872,"about_ca_topic_score_gemma":0.0002405192,"domain_scores_codex":[0.9984511,0.0001165392,0.0001524386,0.0003936739,0.0003080634,0.0005782169],"domain_scores_gemma":[0.9991425,0.0001539052,0.00001583898,0.000379743,0.0001896527,0.0001183575],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003069771,0.00002539219,0.00001283676,0.00007549029,0.000150341,0.000001917059,0.0001195233,0.000004806011,0.7017868,0.00296794,0.07026462,0.2242834],"study_design_scores_gemma":[0.0002224824,0.00008500704,0.00004767894,0.00001012824,0.0000173764,0.000005026645,0.0001082936,0.0001391221,0.2262854,0.0004770337,0.7725222,0.00008026726],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.2123163,0.7726004,0.00052524,0.004970816,0.003267671,0.001289077,0.0003292879,0.0000618753,0.004639318],"genre_scores_gemma":[0.8481773,0.1024821,0.0003523495,0.0001559388,0.01047658,0.00166641,0.00006669378,0.00008798057,0.03653474],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.7022575,"threshold_uncertainty_score":0.2823783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05418229981506786,"score_gpt":0.4105561459189012,"score_spread":0.3563738461038333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}