{"id":"W4393220750","doi":"10.1101/2024.03.23.586441","title":"Puberty Blocker and Aging Impact on Testicular Cell States and Function","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Sperm and Testicular Function","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institute for Research in Immunology and Cancer","funders":"National Cancer Institute","keywords":"Testicular atrophy; Atrophy; Cell; Biology; Biorepository; Disorders of sex development; Internal medicine; Cell type; Germ cell; Juvenile; Endocrinology; Medicine; Physiology; Gene; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003843612,0.000294546,0.000415746,0.0004203634,0.0002752114,0.0006064281,0.0003209739,0.0003101867,0.001702485],"category_scores_gemma":[0.0008753881,0.0001309122,0.00058841,0.000398044,0.0002361534,0.0002716046,0.0004090955,0.00039702,0.0006875861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003308324,"about_ca_system_score_gemma":0.0004596006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005132745,"about_ca_topic_score_gemma":0.01392677,"domain_scores_codex":[0.9997773,0.00004060747,0.0000195668,0.0000972845,0.00003792786,0.0000273911],"domain_scores_gemma":[0.9997668,0.00008142863,0.00004397599,0.00004102321,0.00003986783,0.00002689373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00122582,0.0001383201,0.8041757,0.0009065761,0.0004675938,0.0009555966,0.0004895552,0.02242452,0.051909,0.001150847,0.0196835,0.09647296],"study_design_scores_gemma":[0.00008550475,0.0005458609,0.8454553,0.0002376066,0.0004628058,0.003352217,0.0008251884,0.04728669,0.03250323,0.003074111,0.06609569,0.00007568038],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9016969,0.004748936,0.01074606,0.0005347252,0.00009819839,0.00006604691,0.07751755,0.000830269,0.003761279],"genre_scores_gemma":[0.8281189,0.002270162,0.01177415,0.0004274003,0.00006273943,0.0001169223,0.1544926,0.0001516398,0.002585407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005132745,"threshold_uncertainty_score":0.01020575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00878881277717344,"score_gpt":0.2212086550340437,"score_spread":0.2124198422568702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}