{"id":"W4393230660","doi":"10.1016/j.leukres.2024.107497","title":"Somatic gene mutation patterns and burden influence outcomes with enasidenib in relapsed/refractory IDH2-mutated AML","year":2024,"lang":"en","type":"article","venue":"Leukemia Research","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"Medical Research Council; Bristol-Myers Squibb","keywords":"IDH2; Neuroblastoma RAS viral oncogene homolog; Internal medicine; Medicine; Oncology; Mutation; Myeloid; IDH1; Biology; Gene; Genetics; KRAS","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005344827,0.0001380479,0.0003053821,0.000171454,0.0001078644,0.0004671541,0.0001579879,0.0001925942,0.001456317],"category_scores_gemma":[0.001259617,0.00008692052,0.0002657102,0.0002394059,0.00014939,0.0002720887,0.0002524482,0.000384705,0.0001890886],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001938127,"about_ca_system_score_gemma":0.0001866798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005281853,"about_ca_topic_score_gemma":0.001371493,"domain_scores_codex":[0.999778,0.00006591297,0.00002140575,0.00006211895,0.00004197202,0.00003065697],"domain_scores_gemma":[0.9995418,0.0001554666,0.0001538084,0.00003606426,0.00002726144,0.00008565151],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005905988,0.0001430766,0.938198,0.00005593383,0.0003850244,0.0002424061,0.00009781501,0.001009916,0.0105823,0.0001509871,0.0005007065,0.04272779],"study_design_scores_gemma":[0.00008090699,0.0005868243,0.9936966,0.00001390531,0.0002270684,0.0004812234,0.00007554095,0.001528909,0.001857562,0.0002673132,0.001175823,0.000008343613],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985404,0.0006731237,0.00009662045,0.00006453717,0.000004854284,0.000003774922,0.0001632349,0.00000494412,0.0004485807],"genre_scores_gemma":[0.9992975,0.0001638056,0.0000692506,0.00003734294,0.00001079156,0.000002890832,0.0002403547,0.00000334339,0.0001745835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001456317,"threshold_uncertainty_score":0.004871905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03134948617511376,"score_gpt":0.3557072773481268,"score_spread":0.3243577911730131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}