{"id":"W4393233373","doi":"10.7554/elife.95708.1.sa4","title":"Author Response: #GotGlycans: Role of N343 Glycosylation on the SARS-CoV-2 S RBD Structure and Co-Receptor Binding Across Variants of Concern","year":2024,"lang":"en","type":"peer-review","venue":"","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Irish Centre for High-End Computing; Irish Research Council; Science Foundation Ireland","keywords":"Glycosylation; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); N-linked glycosylation; Computational biology; Coronavirus disease 2019 (COVID-19); Receptor; Biology; Genetics; Medicine; Glycoprotein; Glycan; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009989172,0.0007589879,0.0007172942,0.0004034613,0.001479036,0.002397076,0.0009064085,0.005249169,0.3133088],"category_scores_gemma":[0.00704316,0.0003473278,0.00073459,0.0003378137,0.0008017649,0.00122818,0.001827024,0.003348174,0.1145872],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001279009,"about_ca_system_score_gemma":0.001875629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002759666,"about_ca_topic_score_gemma":0.005178413,"domain_scores_codex":[0.999128,0.0001621404,0.00006452441,0.0001537198,0.0003360143,0.0001555765],"domain_scores_gemma":[0.9973342,0.0006777074,0.0001474183,0.0001339973,0.001184016,0.0005225921],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001284448,0.00001007689,0.0002257298,0.000109039,0.000004822052,0.00006432248,0.00003226279,0.00005312968,0.0002000969,0.000266882,0.993277,0.005628346],"study_design_scores_gemma":[0.00006053938,0.00005500715,0.0008235876,0.0001541037,0.000007567353,0.00009888085,0.0002606836,0.0001823654,0.0004594967,0.0006035664,0.9972695,0.000024642],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.006080654,0.004051703,0.001926143,0.5399908,0.2832156,0.0004635786,0.01281661,0.004069356,0.1473857],"genre_scores_gemma":[0.03357054,0.003653139,0.002016588,0.2903214,0.03487508,0.0005006512,0.005721137,0.001890185,0.6274512],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.3133088,"threshold_uncertainty_score":0.9794816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04562336274056092,"score_gpt":0.3659692526556851,"score_spread":0.3203458899151241,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}