{"id":"W4393236029","doi":"10.1097/hep.0000000000000869","title":"Comprehensive molecular classification predicted microenvironment profiles and therapy response for HCC","year":2024,"lang":"en","type":"article","venue":"Hepatology","topic":"Single-cell and spatial transcriptomics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Tumor microenvironment; Medicine; Computational biology; Cancer research; Oncology; Internal medicine; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004552413,0.0002706747,0.0002932973,0.001073178,0.0001873487,0.0004478885,0.0001471657,0.000231431,0.0007373706],"category_scores_gemma":[0.0007862767,0.00007101073,0.0002935267,0.0005237951,0.0001409479,0.0001849286,0.0003374188,0.0002319618,0.0001316738],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000366639,"about_ca_system_score_gemma":0.0003231095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009785099,"about_ca_topic_score_gemma":0.001313295,"domain_scores_codex":[0.9998574,0.00002231272,0.00001541702,0.00004497813,0.00002898116,0.00003091977],"domain_scores_gemma":[0.9995993,0.0001150108,0.0001241339,0.00004098608,0.00007024358,0.00005037755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005542545,0.0000966299,0.8974387,0.00005010437,0.0001387699,0.00007033638,0.00006514991,0.01133946,0.05330286,0.0001458861,0.0004528739,0.03634507],"study_design_scores_gemma":[0.00002143361,0.0002635353,0.9092073,0.00001218818,0.0001650495,0.0002694179,0.000123201,0.07322016,0.01495766,0.0007785684,0.0009626515,0.00001869439],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954965,0.0001641294,0.003510726,0.00002969582,0.000002505216,0.00002076961,0.0005462869,0.00003932219,0.0001900167],"genre_scores_gemma":[0.9966702,0.00003452825,0.002018679,0.000009389078,0.000004435221,0.00001800311,0.001148301,0.000003568372,0.00009305254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001073178,"threshold_uncertainty_score":0.002660215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02611121881328227,"score_gpt":0.2639132632735969,"score_spread":0.2378020444603146,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}