{"id":"W4393241699","doi":"10.2139/ssrn.4774467","title":"Not All Microsomes are Created Equal: Effects of Species of Origin and Mode of Induction on the Metabolic Activity of in Vitro Liver Microsomes","year":2024,"lang":"en","type":"preprint","venue":"SSRN Electronic Journal","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Microsome; In vitro; Metabolic activity; Chemistry; Biochemistry; Microsoma; Biology; Physiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002324628,0.0006204891,0.0009512242,0.0005082541,0.0003491268,0.001007899,0.0004935509,0.000554644,0.002757431],"category_scores_gemma":[0.003288519,0.0006218253,0.0006621535,0.0005905502,0.0005985213,0.001223597,0.0005269013,0.001191483,0.0009952665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003334742,"about_ca_system_score_gemma":0.0004093827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004702899,"about_ca_topic_score_gemma":0.0005144214,"domain_scores_codex":[0.9983441,0.0009302106,0.0001068877,0.0002768619,0.0001693078,0.0001726344],"domain_scores_gemma":[0.9954221,0.002283602,0.0005169791,0.001191533,0.0003471126,0.0002387107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01155458,0.0001993514,0.001623104,0.0001659806,0.00011777,0.0001729207,0.0001464333,0.0003838729,0.974331,0.00108413,0.0002362059,0.009984611],"study_design_scores_gemma":[0.00004177449,0.0009087736,0.003390299,0.000007794835,0.000119566,0.0002189211,0.00003635545,0.0008769839,0.9927154,0.0005801625,0.001092033,0.00001197776],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9777623,0.003091553,0.0140066,0.0005028341,0.0002537854,0.0001047262,0.0005433294,0.0002565929,0.003478185],"genre_scores_gemma":[0.9858842,0.001189207,0.007737201,0.0001263343,0.00007193427,0.00003777077,0.0009940141,0.0002256014,0.003733738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002757431,"threshold_uncertainty_score":0.01229393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02123396969929822,"score_gpt":0.2838110763291998,"score_spread":0.2625771066299016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}