{"id":"W4393253949","doi":"10.3390/brainsci14040328","title":"Natural Compounds Oridonin and Shikonin Exhibit Potentially Beneficial Regulatory Effects on Select Functions of Microglia","year":2024,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; University of British Columbia","funders":"","keywords":"Microglia; Neuroscience; Natural (archaeology); Chemistry; Biology; Computational biology; Business; Biochemical engineering; Engineering; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008300695,0.0001715228,0.0001959582,0.0002052081,0.0004786337,0.00009945134,0.0002172187,0.0001220444,0.00008863916],"category_scores_gemma":[0.00006477071,0.0001395152,0.00008912443,0.0004925719,0.0006113391,0.0001609897,0.00007501503,0.0003775172,0.00002805272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003418333,"about_ca_system_score_gemma":0.0001400858,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001615955,"about_ca_topic_score_gemma":0.00002330821,"domain_scores_codex":[0.9985993,0.0002291681,0.0002038014,0.0004219475,0.0002327629,0.0003130255],"domain_scores_gemma":[0.9989973,0.000708472,0.00006233324,0.00008615846,0.00005052174,0.00009516619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000156831,0.0001612091,0.008394426,0.0001920863,0.0001451772,0.00005385323,0.0003644927,0.00006533931,0.9104097,0.01088332,0.03391743,0.03525606],"study_design_scores_gemma":[0.001977989,0.00203532,0.1129422,0.0004897364,0.0002928302,0.0001744827,0.0003752109,0.01170783,0.6636373,0.002216908,0.2031935,0.0009567273],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879266,0.004287108,0.00004063211,0.002059724,0.003371504,0.00018487,0.00002880472,0.00007629629,0.002024435],"genre_scores_gemma":[0.997435,0.00004672988,0.0001542017,0.0008972757,0.0003740195,0.000007594298,0.0000063606,0.00001008572,0.001068678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2467724,"threshold_uncertainty_score":0.5689264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05616266598585529,"score_gpt":0.3870037681981915,"score_spread":0.3308411022123362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}