{"id":"W4393254411","doi":"10.3390/ijms25073779","title":"Comprehensive Analysis of Lung Adenocarcinoma and Brain Metastasis through Integrated Single-Cell Transcriptomics","year":2024,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital","funders":"BC Cancer Foundation; Terry Fox Foundation; University of British Columbia; Canadian Institutes of Health Research; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Lotte and John Hecht Memorial Foundation","keywords":"Microglia; Immune system; Brain metastasis; Tumor microenvironment; Metastasis; Cancer research; Adenocarcinoma; Biology; Immunotherapy; Lung cancer; Cell type; Cell; Cancer; Medicine; Immunology; Pathology; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004814549,0.0004237187,0.000821211,0.000908423,0.0005744948,0.0008381463,0.0003446442,0.0005050578,0.001381701],"category_scores_gemma":[0.0006566631,0.0002185261,0.0006783967,0.0010627,0.0002464898,0.0002558881,0.0005755397,0.0008441705,0.0007755063],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003967643,"about_ca_system_score_gemma":0.0008364056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003962488,"about_ca_topic_score_gemma":0.01107026,"domain_scores_codex":[0.9995808,0.00002602002,0.00002488495,0.000173086,0.0001250052,0.00007022244],"domain_scores_gemma":[0.9997196,0.00008145213,0.00004802249,0.00002302484,0.0001006724,0.00002720588],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000616001,0.0001047344,0.06974108,0.002468234,0.0006715945,0.0008731021,0.0004582037,0.00457342,0.8505259,0.001476319,0.008698422,0.05979304],"study_design_scores_gemma":[0.0001125404,0.000531793,0.6802866,0.0004929507,0.001360537,0.002240326,0.001243012,0.03845771,0.1560999,0.004338134,0.1146055,0.000230866],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7597942,0.02092366,0.04523898,0.0006893149,0.000302809,0.000285335,0.1635377,0.001540756,0.007687224],"genre_scores_gemma":[0.7554874,0.00873317,0.05155732,0.001205142,0.0001349109,0.0008572169,0.1761613,0.0007323017,0.005131139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003962488,"threshold_uncertainty_score":0.00787884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03461556070131667,"score_gpt":0.3219125715057684,"score_spread":0.2872970108044517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}