{"id":"W4393254619","doi":"10.1038/s41564-024-01672-3","title":"Crimean–Congo haemorrhagic fever virus uses LDLR to bind and enter host cells","year":2024,"lang":"en","type":"article","venue":"Nature Microbiology","topic":"Viral Infections and Vectors","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Horizon 2020 Framework Programme; National Institutes of Health; Vetenskapsrådet; Svenska Sällskapet för Medicinsk Forskning; Università degli Studi di Padova; Karolinska Institutet; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; European Commission; Texas Biomedical Research Institute","keywords":"LDL receptor; Virology; Biology; Glycoprotein; Virus; Antibody; Population; Receptor; Lipoprotein; Immunology; Molecular biology; Medicine; Cholesterol; Genetics; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008126157,0.0001740063,0.0002569946,0.000245812,0.00005630547,0.00003592164,0.00005407241,0.0004448199,0.0005869495],"category_scores_gemma":[0.00003023849,0.000125611,0.00008335718,0.0002234753,0.00008420764,0.00004386077,0.00007056058,0.0006381604,0.0005319887],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005089341,"about_ca_system_score_gemma":0.00003969112,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007942225,"about_ca_topic_score_gemma":0.00008509662,"domain_scores_codex":[0.9991567,0.00003581556,0.0001503139,0.0003751583,0.00002754299,0.0002544372],"domain_scores_gemma":[0.9995978,0.00005665027,0.00001672301,0.0001766871,0.00005096152,0.0001011666],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003670978,0.00003996777,0.00100294,0.00005186766,0.00007508897,0.00008804044,0.0001315441,3.182127e-7,0.9252784,0.0001146375,0.07227266,0.000907801],"study_design_scores_gemma":[0.0003794711,0.0003909509,0.003273005,0.00008450092,0.0001014814,0.0008844478,0.00002604219,0.000007555344,0.2875817,0.00001502162,0.707087,0.0001688921],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887407,0.005848726,0.00005375257,0.001895919,0.002038508,0.0002874299,0.0001211922,0.0001107706,0.0009030431],"genre_scores_gemma":[0.9888455,0.00009540384,0.0002982555,0.00574227,0.0003509184,0.000007622062,0.00004906371,0.00002621927,0.004584795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6376967,"threshold_uncertainty_score":0.6837816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008043954589986675,"score_gpt":0.2860265110184599,"score_spread":0.2779825564284732,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}