{"id":"W4393274863","doi":"10.1080/10428194.2024.2333451","title":"Olutasidenib in post-venetoclax patients with mutant isocitrate dehydrogenase 1 (m <i>IDH1</i> ) acute myeloid leukemia (AML)","year":2024,"lang":"en","type":"article","venue":"Leukemia & lymphoma/Leukemia and lymphoma","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Venetoclax; IDH1; Isocitrate dehydrogenase; Myeloid leukemia; Internal medicine; Medicine; Refractory (planetary science); Complete remission; Gastroenterology; Myeloid; Leukemia; Oncology; Chemotherapy; Mutant; Chemistry; Biology; Chronic lymphocytic leukemia; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002971352,0.0001410067,0.0003158603,0.000111919,0.0001672569,0.0002473192,0.0001168544,0.0001455291,0.0005726623],"category_scores_gemma":[0.0003599121,0.00007473653,0.0001434426,0.0001390671,0.0001594647,0.000159381,0.0001217572,0.0005611992,0.0001430974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002081032,"about_ca_system_score_gemma":0.0002107365,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004512846,"about_ca_topic_score_gemma":0.001541877,"domain_scores_codex":[0.9999021,0.00004849581,0.000008641616,0.00001011796,0.00001134848,0.00001935024],"domain_scores_gemma":[0.9998299,0.00004880091,0.00004782403,0.00001172496,0.00000900743,0.00005273372],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.09515,0.00600331,0.1798138,0.0006480601,0.0004816835,0.004151831,0.0009556526,0.002390489,0.1546147,0.0004363425,0.003611054,0.5517431],"study_design_scores_gemma":[0.02701821,0.2424498,0.6133093,0.0001877872,0.0009441065,0.01763963,0.0004733954,0.005763183,0.06530192,0.0004731383,0.0263783,0.0000612057],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970824,0.001910449,0.0001419629,0.00007279749,0.00001260249,0.00002920553,0.00004890735,0.00001431521,0.000687207],"genre_scores_gemma":[0.9989434,0.000525258,0.0001631593,0.00005516631,0.00002004878,0.00001057122,0.00009088597,0.000001699984,0.0001898882],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005726623,"threshold_uncertainty_score":0.001915693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006680696083015651,"score_gpt":0.2386489908476709,"score_spread":0.2319682947646552,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}