{"id":"W4393276355","doi":"10.3389/fonc.2024.1370565","title":"Centrosomes and associated proteins in pathogenesis and treatment of breast cancer","year":2024,"lang":"en","type":"article","venue":"Frontiers in Oncology","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"St Joseph's Health Care; Lawson Health Research Institute; Western University","funders":"Academic Medical Organization of Southwestern Ontario; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Centrosome; Biology; Breast cancer; Cancer research; Cancer; Mitosis; Chromosome instability; PLK1; Genome instability; Kinase; Bioinformatics; Cell cycle; Cell biology; Genetics; DNA damage; Chromosome; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002896457,0.0004110497,0.0006244105,0.001210337,0.0001921357,0.0005138987,0.0004877265,0.000674725,0.002040772],"category_scores_gemma":[0.000380201,0.0001140612,0.000330108,0.0007563327,0.0002177324,0.0004964534,0.000449924,0.0009946442,0.0008650235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005522791,"about_ca_system_score_gemma":0.0005683893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006119022,"about_ca_topic_score_gemma":0.00124535,"domain_scores_codex":[0.9998382,0.00002773518,0.00002306711,0.00002273649,0.00006863383,0.0000195477],"domain_scores_gemma":[0.9998765,0.0000379168,0.00002643722,0.00000367481,0.00003820646,0.00001722143],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000255192,0.0001157932,0.0005927233,0.01099373,0.0001065457,0.0005584577,0.0001137323,0.0005222122,0.01483906,0.002847438,0.03401686,0.9350384],"study_design_scores_gemma":[0.0000682905,0.0004012329,0.003995938,0.002050227,0.0001575605,0.003366859,0.00008267636,0.0002677458,0.00559288,0.002180712,0.9818063,0.00002954057],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006287819,0.9977884,0.0001338097,0.0003315722,0.0001808131,0.00000517799,0.00002242279,0.00001220805,0.0008967411],"genre_scores_gemma":[0.005445875,0.9926878,0.000282279,0.0002367591,0.0003184708,0.00001052041,0.00008871923,0.000003572539,0.0009260334],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002040772,"threshold_uncertainty_score":0.006827056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005647418136304743,"score_gpt":0.2509250681483496,"score_spread":0.2452776500120449,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}