{"id":"W4393278978","doi":"10.3390/molecules29071511","title":"Sea Cucumber and Blueberry Extracts Suppress Inflammation and Reduce Acute Lung Injury through the Regulation of NF-κB/MAPK/JNK Signaling Pathway in Lipopolysaccharide-Treated C57BL/6 Mice","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Echinoderm biology and ecology","field":"Agricultural and Biological Sciences","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Mitacs; Dalhousie University","keywords":"MAPK/ERK pathway; Proinflammatory cytokine; Kinase; Tumor necrosis factor alpha; Pharmacology; Inflammation; IκBα; Signal transduction; Lipopolysaccharide; p38 mitogen-activated protein kinases; Ribosomal s6 kinase; Western blot; Medicine; NF-κB; Chemistry; Biology; Immunology; Protein kinase B; Cell biology; Biochemistry; P70-S6 Kinase 1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000202551,0.0001208664,0.0001479416,0.00001919208,0.0001203522,0.00004834479,0.00009259424,0.0001813565,0.00004743747],"category_scores_gemma":[0.00003600927,0.00004949572,0.00002841192,0.0001549789,0.0001318215,0.0002145968,0.00007089916,0.0001541735,0.000002795401],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001174824,"about_ca_system_score_gemma":0.000007746096,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00106092,"about_ca_topic_score_gemma":0.002164657,"domain_scores_codex":[0.9991149,0.0001440964,0.0002326408,0.000263993,0.00006920646,0.0001752173],"domain_scores_gemma":[0.9995643,0.0002611845,0.00007432113,0.00004582397,0.00002848157,0.00002584324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004734482,0.00001272185,0.008742865,0.00002301609,0.00002800687,0.000007913325,0.0005697132,0.00001932303,0.9826673,0.0009638483,0.00006875907,0.006849149],"study_design_scores_gemma":[0.0001021961,0.0001078922,0.06161119,0.00008976075,0.0000388946,0.00003005422,0.000213961,0.003658707,0.9301687,0.003430271,0.0003960652,0.0001523389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965733,0.001177164,0.000006211022,0.001715231,0.00007998635,0.0001877497,0.00003115074,0.00003873479,0.0001905003],"genre_scores_gemma":[0.9994845,0.0001435229,0.00005621537,0.00006829033,0.00007523656,0.00001620215,0.00006290792,0.000001689813,0.00009139051],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05286833,"threshold_uncertainty_score":0.2018377,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117946854899486,"score_gpt":0.2384967366013328,"score_spread":0.2273172680523379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}