{"id":"W4393278978","doi":"10.3390/molecules29071511","title":"Sea Cucumber and Blueberry Extracts Suppress Inflammation and Reduce Acute Lung Injury through the Regulation of NF-κB/MAPK/JNK Signaling Pathway in Lipopolysaccharide-Treated C57BL/6 Mice","year":2024,"lang":"en","type":"article","venue":"Molecules","topic":"Echinoderm biology and ecology","field":"Agricultural and Biological Sciences","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Mitacs; Dalhousie University","keywords":"MAPK/ERK pathway; Proinflammatory cytokine; Kinase; Tumor necrosis factor alpha; Pharmacology; Inflammation; IκBα; Signal transduction; Lipopolysaccharide; p38 mitogen-activated protein kinases; Ribosomal s6 kinase; Western blot; Medicine; NF-κB; Chemistry; Biology; Immunology; Protein kinase B; Cell biology; Biochemistry; P70-S6 Kinase 1","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002307251,0.001081272,0.0005936784,0.0007328459,0.0002424193,0.0002643669,0.0003532741,0.0004062748,0.00175252],"category_scores_gemma":[0.0001164886,0.0002564068,0.0004730706,0.0002139149,0.0004339336,0.0004587128,0.0002405938,0.001038054,0.0002770123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002743728,"about_ca_system_score_gemma":0.0003672773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001100613,"about_ca_topic_score_gemma":0.002021032,"domain_scores_codex":[0.9998119,0.00002498888,0.00001837542,0.00004284512,0.00004851175,0.00005336755],"domain_scores_gemma":[0.9998429,0.000007472192,0.00005389098,0.00001072273,0.00002043358,0.00006468985],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001688433,0.0005523393,0.000304876,0.0001848833,0.0000228837,0.00008084592,0.00003695449,0.0000675761,0.9943926,0.00004296021,0.00008255344,0.002543238],"study_design_scores_gemma":[0.0004829494,0.010984,0.02758908,0.00007034468,0.0001590642,0.000429776,0.0002040291,0.001808851,0.9542267,0.0001829669,0.003828937,0.00003333461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932208,0.003571944,0.001338338,0.0002783108,0.0001063501,0.00005831375,0.0005177446,0.0001453888,0.0007628502],"genre_scores_gemma":[0.9879325,0.002929576,0.003198859,0.0002271507,0.00004546619,0.000181214,0.0005670957,0.00004284436,0.004875222],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00175252,"threshold_uncertainty_score":0.005862772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01117946854899486,"score_gpt":0.2384967366013328,"score_spread":0.2273172680523379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}