{"id":"W4393281898","doi":"10.1016/j.jhep.2024.03.035","title":"Opportunities and barriers in omics-based biomarker discovery for steatotic liver diseases","year":2024,"lang":"en","type":"review","venue":"Journal of Hepatology","topic":"Liver Disease Diagnosis and Treatment","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"Horizon 2020 Framework Programme; Novo Nordisk Fonden; Faculty of Health and Medical Sciences, University of Western Australia; Horizon 2020; Julius-Maximilians-Universität Würzburg; Syddansk Universitet; Vlaamse regering; Odense Universitetshospital; KU Leuven; Novo Nordisk Foundation Center for Basic Metabolic Research; Novo Nordisk; Bundesministerium für Bildung und Forschung; Det Sundhedsvidenskabelige Fakultet, Københavns Universitet; Deutsche Forschungsgemeinschaft; Westfälische Wilhelms-Universität Münster; Boehringer Ingelheim Fonds; Hessisches Ministerium für Wissenschaft und Kunst; European Commission; Steno Diabetes Center Copenhagen; CSL Behring; European Molecular Biology Laboratory; Fonds Wetenschappelijk Onderzoek","keywords":"Biomarker discovery; Omics; Biomarker; Computational biology; Medicine; Data science; Bioinformatics; Biology; Computer science; Proteomics; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.1188142,0.0015457,0.00359976,0.00343975,0.001560166,0.01192971,0.00454191,0.004204198,0.003473203],"category_scores_gemma":[0.1434387,0.001013062,0.00214543,0.003391738,0.008049269,0.01180132,0.01085451,0.01127028,0.002673239],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003857584,"about_ca_system_score_gemma":0.01130088,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003596548,"about_ca_topic_score_gemma":0.002480631,"domain_scores_codex":[0.9422668,0.03265727,0.00431441,0.005774247,0.01353638,0.001451004],"domain_scores_gemma":[0.7576392,0.1879748,0.006653228,0.01261621,0.03093261,0.00418392],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001022284,0.0003341867,0.02212571,0.01922179,0.001171731,0.0008784424,0.005529944,0.009122503,0.01245965,0.2466932,0.07213047,0.60931],"study_design_scores_gemma":[0.0001095588,0.0004498483,0.01350846,0.01385622,0.0003736519,0.001490052,0.004792332,0.01259359,0.006105304,0.439178,0.5071574,0.0003856938],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"review","genre_scores_codex":[0.02183995,0.3360818,0.1623708,0.4554186,0.004884171,0.0005267397,0.002498679,0.0009758063,0.01540352],"genre_scores_gemma":[0.2340621,0.2865033,0.333242,0.1230283,0.01157579,0.002269333,0.003928904,0.0009004353,0.004489806],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.1188142,"threshold_uncertainty_score":0.6283571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1071192050274898,"score_gpt":0.3652333572921077,"score_spread":0.2581141522646179,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}