{"id":"W4393282627","doi":"10.1016/j.jaad.2024.03.025","title":"Efficacy and safety of tildrakizumab for the treatment of moderate-to-severe plaque psoriasis of the scalp: A multicenter, randomized, double-blind, placebo-controlled, Phase 3b study","year":2024,"lang":"en","type":"article","venue":"Journal of the American Academy of Dermatology","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research","funders":"Sun Pharma; Amgen","keywords":"Medicine; Scalp; Placebo; Dermatology; Multicenter study; Psoriasis; Plaque psoriasis; Adverse effect; Double blind; Randomized controlled trial; Surgery; Internal medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003056974,0.001190335,0.002241358,0.0003194514,0.0004711479,0.0009174323,0.0008350202,0.001265286,0.005234279],"category_scores_gemma":[0.001343878,0.000529923,0.001815365,0.0003810864,0.0007833615,0.0007321377,0.0002564823,0.002319406,0.0010341],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005320685,"about_ca_system_score_gemma":0.00137923,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005906051,"about_ca_topic_score_gemma":0.001263039,"domain_scores_codex":[0.9991686,0.0004388047,0.00005869575,0.0001201307,0.0001225178,0.00009114701],"domain_scores_gemma":[0.9989545,0.0001972773,0.0003439358,0.00008758255,0.000103646,0.0003130642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8944658,0.02661374,0.002332615,0.001544869,0.00191041,0.00008860773,0.000110488,0.0004090047,0.02916319,0.0001163168,0.002356415,0.04088862],"study_design_scores_gemma":[0.9135221,0.0774101,0.005775517,0.00004606216,0.0005900737,0.0001020386,0.00001560469,0.0003157017,0.001253043,0.00008547048,0.0008687628,0.00001567368],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9814091,0.007673274,0.00119931,0.0007465144,0.0002716927,0.004976561,0.001554083,0.000172052,0.001997458],"genre_scores_gemma":[0.9868861,0.003221119,0.002129067,0.001200281,0.0003125231,0.003436551,0.001296532,0.00004567597,0.001472254],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005234279,"threshold_uncertainty_score":0.01751035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02532984566309053,"score_gpt":0.3236869785360868,"score_spread":0.2983571328729963,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}