{"id":"W4393282846","doi":"10.1200/po.23.00487","title":"Human Epidermal Growth Factor Receptor 2–Low Breast Cancer Brain Metastases: An Opportunity for Targeted Systemic Therapies in a High-Need Patient Population","year":2024,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Health Sciences Centre; Statistics Canada; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Trastuzumab; Breast cancer; Immunohistochemistry; Oncology; Internal medicine; Progesterone receptor; Human Epidermal Growth Factor Receptor 2; Cancer; Estrogen receptor; Fluorescence in situ hybridization; Population; Cohort; Gynecology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001893022,0.0001260273,0.0002595561,0.0002933507,0.000306475,0.0004290491,0.0001240575,0.0001785622,0.001741007],"category_scores_gemma":[0.0005040115,0.0000788757,0.000115315,0.0002583978,0.0001897308,0.0003882818,0.0002844168,0.0002458725,0.0002470017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001868909,"about_ca_system_score_gemma":0.0002565342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000848059,"about_ca_topic_score_gemma":0.002393883,"domain_scores_codex":[0.9998902,0.00002776382,0.000008930972,0.00002010435,0.00002316398,0.00002980362],"domain_scores_gemma":[0.9998295,0.00003294246,0.00005990826,0.000007702418,0.0000173238,0.00005260326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0004075239,0.00008588132,0.9688709,0.00003574703,0.00002325873,0.002757665,0.00009478811,0.0001292819,0.004000655,0.0002107178,0.001059127,0.02232443],"study_design_scores_gemma":[0.00005492425,0.0006048618,0.9691608,0.00003948756,0.00005271145,0.0230236,0.001129678,0.001145022,0.0009923353,0.0006132572,0.003171278,0.0000120394],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969001,0.0008627771,0.0002805603,0.0005102495,0.000009712843,0.00001789627,0.0001152777,0.000004794593,0.001298611],"genre_scores_gemma":[0.9988476,0.0004143137,0.0001728956,0.0001866493,0.00004853785,0.00001078276,0.0001174335,0.00000247124,0.0001992775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001741007,"threshold_uncertainty_score":0.005824327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03903125623679429,"score_gpt":0.3569891255609682,"score_spread":0.3179578693241739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}