{"id":"W4393282846","doi":"10.1200/po.23.00487","title":"Human Epidermal Growth Factor Receptor 2–Low Breast Cancer Brain Metastases: An Opportunity for Targeted Systemic Therapies in a High-Need Patient Population","year":2024,"lang":"en","type":"article","venue":"JCO Precision Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Health Sciences Centre; Statistics Canada; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Medicine; Trastuzumab; Breast cancer; Immunohistochemistry; Oncology; Internal medicine; Progesterone receptor; Human Epidermal Growth Factor Receptor 2; Cancer; Estrogen receptor; Fluorescence in situ hybridization; Population; Cohort; Gynecology; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008276877,0.0003206943,0.0008196846,0.0004235603,0.0001288647,0.00004422648,0.0001095599,0.0002528239,0.001449791],"category_scores_gemma":[0.000225172,0.0002349501,0.0002094713,0.000304244,0.00005163207,0.0002866794,0.00005123297,0.0002637097,0.00001628514],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009594568,"about_ca_system_score_gemma":0.00037511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002403115,"about_ca_topic_score_gemma":0.0006488676,"domain_scores_codex":[0.9970207,0.0008198391,0.0008062826,0.0006306301,0.0003093549,0.0004131927],"domain_scores_gemma":[0.9983074,0.0006554397,0.0002073753,0.0003364545,0.000183534,0.0003097612],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.003464473,0.00363773,0.01861496,0.001187752,0.001239753,0.0004893024,0.005558555,0.0001578262,0.03024885,0.003784414,0.01939299,0.9122234],"study_design_scores_gemma":[0.03298383,0.026772,0.8463194,0.003968701,0.001520988,0.00151945,0.007495934,0.005223345,0.006191301,0.007293294,0.05842103,0.00229078],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866398,0.001247429,0.0003619879,0.006242074,0.0009730421,0.002293914,0.002061608,0.0001513563,0.00002876771],"genre_scores_gemma":[0.9938757,0.0001129499,0.002253743,0.0008867059,0.0002702338,0.0008213497,0.001565217,0.00006137311,0.0001527487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9099326,"threshold_uncertainty_score":0.999463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03903125623679429,"score_gpt":0.3569891255609682,"score_spread":0.3179578693241739,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}