{"id":"W4393295326","doi":"10.1016/j.ebiom.2024.105080","title":"Deconstructing pathological tau by biological process in early stages of Alzheimer disease: a method for quantifying tau spatial spread in neuroimaging","year":2024,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Charles F. and Joanne Knight Alzheimer Disease Research Center, Washington University in St. Louis; Avid Radiopharmaceuticals; National Institute on Aging; Weill Cornell Medical College; Genentech; National Institutes of Health; Dementias Platform UK; UK Dementia Research Institute; Fonds de recherche du Québec; Fleni; Ministry of Science and ICT, South Korea; Deutsches Zentrum für Neurodegenerative Erkrankungen; Eisai; Korea Health Industry Development Institute; Ministry of Science, ICT and Future Planning; University College London; Eli Lilly and Company; BrightFocus Foundation; Alzheimer's Research Trust; Good Ventures Foundation; Centene Corporation; Canadian Institutes of Health Research; Foundation for Barnes-Jewish Hospital; Prothena; Bristol-Myers Squibb; Coins for Alzheimer's Research Trust; American Society of Neuroradiology; Ministry of Health and Welfare; Harvard University; F. Hoffmann-La Roche; Demensförbundet; Japan Agency for Medical Research and Development; Fondation Brain Canada; Korea Dementia Research Center; Biogen; Medical Research Council; Cure Alzheimer's Fund; Alzheimer's Association","keywords":"Tau pathology; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Medicine; Pathological; Disease; Alzheimer's disease; Stage (stratigraphy); Internal medicine; Pathology; Psychology; Oncology; Neuroscience; Psychiatry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001372568,0.0002016441,0.0005283614,0.0005450263,0.00003480605,0.0000252616,0.0001008873,0.00008526008,0.000125392],"category_scores_gemma":[0.0007525217,0.0001420294,0.00009864703,0.0006541109,0.0002701354,0.0001005371,0.00007078386,0.000365097,0.000003715781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003598063,"about_ca_system_score_gemma":0.0001364944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001912761,"about_ca_topic_score_gemma":0.000008321175,"domain_scores_codex":[0.9978068,0.0001677226,0.0005841511,0.0005610642,0.0003811787,0.0004990264],"domain_scores_gemma":[0.9990996,0.0004057857,0.00007368292,0.0001386407,0.00009863993,0.000183611],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0005291632,0.0002944731,0.8298224,0.0006101331,0.00005526169,0.000794828,0.0005063743,9.317104e-7,0.05628672,0.00006819388,0.0001130826,0.1109185],"study_design_scores_gemma":[0.003428854,0.001303773,0.9791011,0.001457738,0.0001611869,0.00006633346,0.0008455653,0.003607393,0.0091171,0.0004612064,0.0002545925,0.0001952211],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811048,0.003915336,0.01128007,0.002208861,0.0001586417,0.001099015,0.00006453908,0.00006163887,0.0001070837],"genre_scores_gemma":[0.9968831,0.00008036628,0.002414138,0.0001705074,0.000134457,0.0001527311,0.0001096176,0.00002312907,0.0000319557],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1492787,"threshold_uncertainty_score":0.579179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07374118890835621,"score_gpt":0.4273694179236959,"score_spread":0.3536282290153397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}