{"id":"W4393304858","doi":"10.1101/2024.03.29.587321","title":"Proteome dynamics reveal Leiomodin 1 as a key regulator of myogenic differentiation","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Leibniz-Gemeinschaft; Deutsche Krebshilfe; Else Kröner-Fresenius-Stiftung; Deutsche Forschungsgemeinschaft; Australian Government; Carl-Zeiss-Stiftung","keywords":"Sirtuin; Cell biology; Sirtuin 1; Chemistry; Business; Biology; Biochemistry; Gene; Downregulation and upregulation; Acetylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009280822,0.0002043177,0.0001371957,0.0002950727,0.000153095,0.000174553,0.0001154433,0.000207679,0.0008471984],"category_scores_gemma":[0.0000764697,0.0001029992,0.0001559745,0.0002011861,0.0001062809,0.0001935727,0.0001423539,0.0002422601,0.0002262059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000204076,"about_ca_system_score_gemma":0.0001124064,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003429892,"about_ca_topic_score_gemma":0.000653193,"domain_scores_codex":[0.9999584,0.000003098587,0.000002239474,0.00001606111,0.00001175131,0.000008337845],"domain_scores_gemma":[0.9999462,0.000006477317,0.00002085684,0.000003299946,0.000008693976,0.00001443648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002895438,0.00000375412,0.0007877848,0.00002076323,0.000003085352,0.0000193257,0.000005288687,0.0000212032,0.9983077,0.0000290008,0.00002811546,0.0007451022],"study_design_scores_gemma":[0.000007836356,0.0001052164,0.1068857,0.00001414207,0.00002737028,0.0003287177,0.00005540514,0.003334431,0.8847674,0.000146578,0.004317361,0.00000975896],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897513,0.002964983,0.005104373,0.00009187205,0.00003212681,0.00001282094,0.001192854,0.00006942854,0.0007802221],"genre_scores_gemma":[0.9868405,0.001769803,0.00727504,0.00009459375,0.00001500959,0.00003016279,0.001720875,0.00002764669,0.002226235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008471984,"threshold_uncertainty_score":0.002834141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00649481582726066,"score_gpt":0.2148331173368855,"score_spread":0.2083383015096249,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}